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Economic evaluations of strategies targeting pre-diagnosis dementia populations : A systematic review

Hoang, Men Thi ; Zenker, Alina LU ; Saha, Sanjib LU orcid ; Gerdtham, Ulf-Göran LU orcid and Trepel, Dominic (2026) In Alzheimer's and Dementia: Translational Research and Clinical Interventions 12(2). p.1-13
Abstract
This review aims to appraise and summarize the best available evidence from economic evaluations (EEs) of strategies targeting populations prior to a diagnosis of dementia. A comprehensive search was conducted in EMBASE, PubMed, EconLit, Web of Science, Cumulative Index to Nursing and Allied Health (CINAHL), and The NHS Economic Evaluation Database (NHS EED). Publications were dually screened and assessed against eligibility criteria, and reporting quality was appraised using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) framework. Seventeen full EEs met the inclusion criteria; all were conducted in high-income countries and covered strategies in identification (29%), risk reduction (65%), and other strategies... (More)
This review aims to appraise and summarize the best available evidence from economic evaluations (EEs) of strategies targeting populations prior to a diagnosis of dementia. A comprehensive search was conducted in EMBASE, PubMed, EconLit, Web of Science, Cumulative Index to Nursing and Allied Health (CINAHL), and The NHS Economic Evaluation Database (NHS EED). Publications were dually screened and assessed against eligibility criteria, and reporting quality was appraised using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) framework. Seventeen full EEs met the inclusion criteria; all were conducted in high-income countries and covered strategies in identification (29%), risk reduction (65%), and other strategies (6%). The number of publications from 2016 to 2025 tripled compared to the preceding periods. Most risk-reduction strategies were cost-effective and exhibited high reporting quality. The average reporting quality, based on the CHEERS framework, was 72%, with a noticeable improvement observed in articles published after 2020. Overall, the findings suggest that most risk-reduction strategies may offer good value for money. However, evidence remains limited, specifically in low- and middle-income countries; therefore, additional EEs are needed to guide future investment in strategies targeting pre-diagnosis dementia populations. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's and Dementia: Translational Research and Clinical Interventions
volume
12
issue
2
article number
e70236
pages
1 - 13
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:42253440
  • scopus:105039833517
ISSN
2352-8737
DOI
10.1002/trc2.70236
language
English
LU publication?
yes
id
5d22691d-0c08-4055-bff1-be211974b9d6
date added to LUP
2026-05-22 06:55:37
date last changed
2026-08-27 17:12:42
@article{5d22691d-0c08-4055-bff1-be211974b9d6,
  abstract     = {{This review aims to appraise and summarize the best available evidence from economic evaluations (EEs) of strategies targeting populations prior to a diagnosis of dementia. A comprehensive search was conducted in EMBASE, PubMed, EconLit, Web of Science, Cumulative Index to Nursing and Allied Health (CINAHL), and The NHS Economic Evaluation Database (NHS EED). Publications were dually screened and assessed against eligibility criteria, and reporting quality was appraised using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) framework. Seventeen full EEs met the inclusion criteria; all were conducted in high-income countries and covered strategies in identification (29%), risk reduction (65%), and other strategies (6%). The number of publications from 2016 to 2025 tripled compared to the preceding periods. Most risk-reduction strategies were cost-effective and exhibited high reporting quality. The average reporting quality, based on the CHEERS framework, was 72%, with a noticeable improvement observed in articles published after 2020. Overall, the findings suggest that most risk-reduction strategies may offer good value for money. However, evidence remains limited, specifically in low- and middle-income countries; therefore, additional EEs are needed to guide future investment in strategies targeting pre-diagnosis dementia populations.}},
  author       = {{Hoang, Men Thi and Zenker, Alina and Saha, Sanjib and Gerdtham, Ulf-Göran and Trepel, Dominic}},
  issn         = {{2352-8737}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{1--13}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Alzheimer's and Dementia: Translational Research and Clinical Interventions}},
  title        = {{Economic evaluations of strategies targeting pre-diagnosis dementia populations : A systematic review}},
  url          = {{http://dx.doi.org/10.1002/trc2.70236}},
  doi          = {{10.1002/trc2.70236}},
  volume       = {{12}},
  year         = {{2026}},
}