Infectivity of exhaled SARS-CoV-2 aerosols is sufficient to transmit covid-19 within minutes
(2023) In Scientific Reports 13.- Abstract
- Exhaled SARS-CoV-2-containing aerosols contributed significantly to the rapid and vast spread of covid-19. However, quantitative experimental data on the infectivity of such aerosols is missing. Here, we quantified emission rates of infectious viruses in exhaled aerosol from individuals within their first days after symptom onset from covid-19. Six aerosol samples from three individuals were culturable, of which five were successfully quantified using TCID50. The source strength of the three individuals was highest during singing, when they exhaled 4, 36, or 127 TCID50/s, respectively. Calculations with an indoor air transmission model showed that if an infected individual with this emission rate entered a room, a susceptible person would... (More)
- Exhaled SARS-CoV-2-containing aerosols contributed significantly to the rapid and vast spread of covid-19. However, quantitative experimental data on the infectivity of such aerosols is missing. Here, we quantified emission rates of infectious viruses in exhaled aerosol from individuals within their first days after symptom onset from covid-19. Six aerosol samples from three individuals were culturable, of which five were successfully quantified using TCID50. The source strength of the three individuals was highest during singing, when they exhaled 4, 36, or 127 TCID50/s, respectively. Calculations with an indoor air transmission model showed that if an infected individual with this emission rate entered a room, a susceptible person would inhale an infectious dose within 6 to 37 min in a room with normal ventilation. Thus, our data show that exhaled aerosols from a single person can transmit covid-19 to others within minutes at normal indoor conditions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5d888d47-194c-4d20-b20e-f9dac82272b1
- author
- Alsved, Malin LU ; Nyström, Kristina ; Thuresson, Sara LU ; Nygren, David LU ; Churqui, Marianela Patzi ; Hussein, Tareq ; Fraenkel, Carl-Johan LU ; Medstrand, Patrik LU and Löndahl, Jakob LU
- organization
-
- Ergonomics and Aerosol Technology
- Metalund
- NanoLund: Centre for Nanoscience
- MERGE: ModElling the Regional and Global Earth system
- Infection Medicine (BMC)
- Translational infection medicine (research group)
- Teachers at the Medical Programme
- EpiHealth: Epidemiology for Health
- Clinical Virology, Malmö (research group)
- publishing date
- 2023-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 13
- article number
- 21245
- pages
- 9 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:38040798
- scopus:85178230617
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-023-47829-8
- language
- English
- LU publication?
- yes
- id
- 5d888d47-194c-4d20-b20e-f9dac82272b1
- date added to LUP
- 2023-12-04 08:58:15
- date last changed
- 2024-04-04 22:34:02
@article{5d888d47-194c-4d20-b20e-f9dac82272b1, abstract = {{Exhaled SARS-CoV-2-containing aerosols contributed significantly to the rapid and vast spread of covid-19. However, quantitative experimental data on the infectivity of such aerosols is missing. Here, we quantified emission rates of infectious viruses in exhaled aerosol from individuals within their first days after symptom onset from covid-19. Six aerosol samples from three individuals were culturable, of which five were successfully quantified using TCID50. The source strength of the three individuals was highest during singing, when they exhaled 4, 36, or 127 TCID50/s, respectively. Calculations with an indoor air transmission model showed that if an infected individual with this emission rate entered a room, a susceptible person would inhale an infectious dose within 6 to 37 min in a room with normal ventilation. Thus, our data show that exhaled aerosols from a single person can transmit covid-19 to others within minutes at normal indoor conditions.}}, author = {{Alsved, Malin and Nyström, Kristina and Thuresson, Sara and Nygren, David and Churqui, Marianela Patzi and Hussein, Tareq and Fraenkel, Carl-Johan and Medstrand, Patrik and Löndahl, Jakob}}, issn = {{2045-2322}}, language = {{eng}}, month = {{12}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Infectivity of exhaled SARS-CoV-2 aerosols is sufficient to transmit covid-19 within minutes}}, url = {{http://dx.doi.org/10.1038/s41598-023-47829-8}}, doi = {{10.1038/s41598-023-47829-8}}, volume = {{13}}, year = {{2023}}, }