Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Coronary artery restenosis and target lesion revascularisation in women by pregnancy history

Pehrson, Moa LU ; Edsfeldt, Andreas LU ; Sarno, Giovanna ; Fraser, Abigail ; Rich-Edwards, Janet W. ; Goncalves, Isabel LU orcid ; Pihlsgård, Mats LU and Timpka, Simon LU orcid (2023) In Open Heart 10(1).
Abstract

Background Women's pregnancy history is associated with incident risk of coronary artery disease with some evidence also suggesting a relevance for prognosis following treatment. Objectives To study the associations between maternal history of preterm delivery, a history of small for gestational age infant, parity and age at first delivery with clinical restenosis after percutaneous coronary intervention (PCI). Methods In this prospective cohort study, we included 6027 women <65 years undergoing their first PCI 2006-2017, merging clinical register data on PCI procedures in Sweden with comprehensive registry data on deliveries since 1973. We used proportional hazards regression to study the association between aspects of pregnancy... (More)

Background Women's pregnancy history is associated with incident risk of coronary artery disease with some evidence also suggesting a relevance for prognosis following treatment. Objectives To study the associations between maternal history of preterm delivery, a history of small for gestational age infant, parity and age at first delivery with clinical restenosis after percutaneous coronary intervention (PCI). Methods In this prospective cohort study, we included 6027 women <65 years undergoing their first PCI 2006-2017, merging clinical register data on PCI procedures in Sweden with comprehensive registry data on deliveries since 1973. We used proportional hazards regression to study the association between aspects of pregnancy history and clinical restenosis in per-segment analyses, and with target lesion revascularisation (TLR) in per-patient analyses. We adjusted models for procedural-related and patient-related predictors of restenosis. Results During 15 981 segment-years of follow-up, 343 (3.7%) events of clinical restenosis occurred. We found no strong evidence of associations between the studied aspects of pregnancy history and clinical restenosis following PCI. For example, the restenosis HR for a history of preterm delivery in the fully adjusted model was 1.09 (95% CI 0.77 to 1.55) and the TLR HR was 1.18 (95% CI 0.91 to 1.52). Conclusion Risk of restenosis following treatment with PCI did not differ by the studied aspects of pregnancy history, including preterm delivery, in young and middle-aged women. Larger studies are needed to obtain more precise estimates.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary artery disease, epidemiology, percutaneous coronary intervention, pregnancy
in
Open Heart
volume
10
issue
1
article number
e002130
publisher
BMJ Publishing Group
external identifiers
  • scopus:85151339239
  • pmid:36931658
ISSN
2398-595X
DOI
10.1136/openhrt-2022-002130
language
English
LU publication?
yes
id
5e45b9d1-b06e-4792-933b-10527629ceea
date added to LUP
2023-05-23 10:52:07
date last changed
2024-06-15 03:13:18
@article{5e45b9d1-b06e-4792-933b-10527629ceea,
  abstract     = {{<p>Background Women's pregnancy history is associated with incident risk of coronary artery disease with some evidence also suggesting a relevance for prognosis following treatment. Objectives To study the associations between maternal history of preterm delivery, a history of small for gestational age infant, parity and age at first delivery with clinical restenosis after percutaneous coronary intervention (PCI). Methods In this prospective cohort study, we included 6027 women &lt;65 years undergoing their first PCI 2006-2017, merging clinical register data on PCI procedures in Sweden with comprehensive registry data on deliveries since 1973. We used proportional hazards regression to study the association between aspects of pregnancy history and clinical restenosis in per-segment analyses, and with target lesion revascularisation (TLR) in per-patient analyses. We adjusted models for procedural-related and patient-related predictors of restenosis. Results During 15 981 segment-years of follow-up, 343 (3.7%) events of clinical restenosis occurred. We found no strong evidence of associations between the studied aspects of pregnancy history and clinical restenosis following PCI. For example, the restenosis HR for a history of preterm delivery in the fully adjusted model was 1.09 (95% CI 0.77 to 1.55) and the TLR HR was 1.18 (95% CI 0.91 to 1.52). Conclusion Risk of restenosis following treatment with PCI did not differ by the studied aspects of pregnancy history, including preterm delivery, in young and middle-aged women. Larger studies are needed to obtain more precise estimates.</p>}},
  author       = {{Pehrson, Moa and Edsfeldt, Andreas and Sarno, Giovanna and Fraser, Abigail and Rich-Edwards, Janet W. and Goncalves, Isabel and Pihlsgård, Mats and Timpka, Simon}},
  issn         = {{2398-595X}},
  keywords     = {{coronary artery disease; epidemiology; percutaneous coronary intervention; pregnancy}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Open Heart}},
  title        = {{Coronary artery restenosis and target lesion revascularisation in women by pregnancy history}},
  url          = {{http://dx.doi.org/10.1136/openhrt-2022-002130}},
  doi          = {{10.1136/openhrt-2022-002130}},
  volume       = {{10}},
  year         = {{2023}},
}