Shared heritability and functional enrichment across six solid cancers
Jiang, Xia ; Brunnström, Hans LU
; Ellberg, Carolina
LU
; Olsson, Håkan
LU
and Lindström, Sara
(2019)
In Nature Communications
10(1).
p.1-23
- Abstract
- Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also... (More)
- Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. © 2019, The Author(s). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5f5c9536-f446-4642-823d-bafa1823de82
- author
- Jiang, Xia
; Brunnström, Hans
LU
; Ellberg, Carolina
LU
; Olsson, Håkan
LU
and Lindström, Sara
- author collaboration
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 10
- issue
- 1
- article number
- 431
- pages
- 1 - 23
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85060528251
- pmid:30683880
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-018-08054-4
- language
- English
- LU publication?
- yes
- additional info
- Export Date: 5 February 2019
- id
- 5f5c9536-f446-4642-823d-bafa1823de82
- date added to LUP
- 2019-02-05 12:04:23
- date last changed
- 2024-01-30 09:32:08
@article{5f5c9536-f446-4642-823d-bafa1823de82,
abstract = {{Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. © 2019, The Author(s).}},
author = {{Jiang, Xia and Brunnström, Hans and Ellberg, Carolina and Olsson, Håkan and Lindström, Sara}},
issn = {{2041-1723}},
language = {{eng}},
number = {{1}},
pages = {{1--23}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{Shared heritability and functional enrichment across six solid cancers}},
url = {{http://dx.doi.org/10.1038/s41467-018-08054-4}},
doi = {{10.1038/s41467-018-08054-4}},
volume = {{10}},
year = {{2019}},
}