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Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme

Holm, Karin LU ; Collin, Mattias LU ; Hagelskjær-Kristensen, Lena; Jensen, Anders and Rasmussen, Magnus LU (2017) In Anaerobe 45. p.129-132
Abstract

Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants were found, two of which have not been described previously. The sequence types correlated to source of infection. Further studies are needed to examine the role of the leukotoxin in human infections.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fusobacterium necrophorum, Lemierre, Leukocidin, Leukotoxin, Pharyngotonsillitis, Sequencing
in
Anaerobe
volume
45
pages
129 - 132
publisher
Elsevier
external identifiers
  • scopus:85016519093
  • wos:000404205400018
ISSN
1075-9964
DOI
10.1016/j.anaerobe.2017.03.016
language
English
LU publication?
yes
id
5f8204c3-c30d-4578-b429-16dbeb69d6d2
date added to LUP
2017-04-19 14:40:23
date last changed
2017-09-18 13:32:42
@article{5f8204c3-c30d-4578-b429-16dbeb69d6d2,
  abstract     = {<p>Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants were found, two of which have not been described previously. The sequence types correlated to source of infection. Further studies are needed to examine the role of the leukotoxin in human infections.</p>},
  author       = {Holm, Karin and Collin, Mattias and Hagelskjær-Kristensen, Lena and Jensen, Anders and Rasmussen, Magnus},
  issn         = {1075-9964},
  keyword      = {Fusobacterium necrophorum,Lemierre,Leukocidin,Leukotoxin,Pharyngotonsillitis,Sequencing},
  language     = {eng},
  month        = {03},
  pages        = {129--132},
  publisher    = {Elsevier},
  series       = {Anaerobe},
  title        = {Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme},
  url          = {http://dx.doi.org/10.1016/j.anaerobe.2017.03.016},
  volume       = {45},
  year         = {2017},
}