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Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season

Samuelsson, U. ; Lindblad, B. ; Carlsson, Annelie LU ; Forsander, G. ; Ivarsson, Sten LU ; Kockum, I. ; Lernmark, Åke LU ; Marcus, C. and Ludvigsson, J. (2013) In Diabetes/Metabolism Research Reviews 29(1). p.85-89
Abstract
Background There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease. We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D. Methods In 2005, a national study, the Better Diabetes Diagnosis, was started to classify all newly diagnosed children and adolescents with diabetes. About 95% (3824/4017) of the patients were classified as T1D, and our analyses are based on the patients with T1D. Results C-peptide was lower in younger children, 010 years of age (0.23 +/- 0.20 nmol/L) than in older children, 1118 years of age (0.34 +/- 0.28 nmol/L) (p < 0.000 ). There... (More)
Background There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease. We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D. Methods In 2005, a national study, the Better Diabetes Diagnosis, was started to classify all newly diagnosed children and adolescents with diabetes. About 95% (3824/4017) of the patients were classified as T1D, and our analyses are based on the patients with T1D. Results C-peptide was lower in younger children, 010 years of age (0.23 +/- 0.20 nmol/L) than in older children, 1118 years of age (0.34 +/- 0.28 nmol/L) (p < 0.000 ). There was a seasonal variation in non-fasting serum C-peptide, significantly correlated to the seasonal variation of diagnosis (p < 0.01). Most children were diagnosed in January, February and March as well as in October when C-peptide was highest, whereas fewer patients were diagnosed in April and May when serum C-peptide was significantly lower (p < 0.01). The seasonal variation of C-peptide was more pronounced in boys than in girls (p < 0.000 and p < 0.01, respectively). Girls had higher C-peptide than boys (p < 0.05), especially in early puberty. Conclusions Both seasonal and gender differences in residual beta cell function exist already at diagnosis of T1D. These observations have consequences for treatment and for randomizing patients in immune intervention clinical trials. Copyright (C) 2012 John Wiley & Sons, Ltd. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-peptide, children, type 1 diabetes, seasonal variation, gender, immune, intervention
in
Diabetes/Metabolism Research Reviews
volume
29
issue
1
pages
85 - 89
publisher
John Wiley and Sons Inc.
external identifiers
  • wos:000313546000013
  • scopus:84872236732
  • pmid:23081842
ISSN
1520-7552
DOI
10.1002/dmrr.2365
language
English
LU publication?
yes
id
5fd06d70-4aac-409f-a3db-e7f3920fee71 (old id 3589717)
date added to LUP
2016-04-01 09:48:12
date last changed
2020-09-09 01:00:15
@article{5fd06d70-4aac-409f-a3db-e7f3920fee71,
  abstract     = {Background There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease. We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D. Methods In 2005, a national study, the Better Diabetes Diagnosis, was started to classify all newly diagnosed children and adolescents with diabetes. About 95% (3824/4017) of the patients were classified as T1D, and our analyses are based on the patients with T1D. Results C-peptide was lower in younger children, 010 years of age (0.23 +/- 0.20 nmol/L) than in older children, 1118 years of age (0.34 +/- 0.28 nmol/L) (p &lt; 0.000 ). There was a seasonal variation in non-fasting serum C-peptide, significantly correlated to the seasonal variation of diagnosis (p &lt; 0.01). Most children were diagnosed in January, February and March as well as in October when C-peptide was highest, whereas fewer patients were diagnosed in April and May when serum C-peptide was significantly lower (p &lt; 0.01). The seasonal variation of C-peptide was more pronounced in boys than in girls (p &lt; 0.000 and p &lt; 0.01, respectively). Girls had higher C-peptide than boys (p &lt; 0.05), especially in early puberty. Conclusions Both seasonal and gender differences in residual beta cell function exist already at diagnosis of T1D. These observations have consequences for treatment and for randomizing patients in immune intervention clinical trials. Copyright (C) 2012 John Wiley &amp; Sons, Ltd.},
  author       = {Samuelsson, U. and Lindblad, B. and Carlsson, Annelie and Forsander, G. and Ivarsson, Sten and Kockum, I. and Lernmark, Åke and Marcus, C. and Ludvigsson, J.},
  issn         = {1520-7552},
  language     = {eng},
  number       = {1},
  pages        = {85--89},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Diabetes/Metabolism Research Reviews},
  title        = {Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season},
  url          = {http://dx.doi.org/10.1002/dmrr.2365},
  doi          = {10.1002/dmrr.2365},
  volume       = {29},
  year         = {2013},
}