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Determinants of health-related quality of life in a multinational systemic sclerosis inception cohort

Morrisroe, Kathleen ; Hudson, Marie ; Baron, Murray ; de Vries-Bouwstra, Jeska ; Carreira, Patricia E. ; Wuttge, Dirk M. LU ; Wang, Mianbo ; Frech, Tracy M. ; Stevens, Wendy and Proudman, Susanna M. , et al. (2018) In Clinical and Experimental Rheumatology 36(4). p.53-60
Abstract

OBJECTIVES: To evaluate health-related quality of life (HRQoL) and its determinants in a systemic sclerosis (SSc) multinational inception cohort. We performed a meta-analysis of data from individual countries, and compared the meta-analysis to individual country results by pooling data from each of the countries.

METHODS: SSc patients within 2 years of disease onset were recruited from 5 countries participating in the International Systemic Sclerosis Inception Cohort (INSYNC). Data from each country's database were exported for analysis using a harmonised platform. HRQoL was assessed using the Medical Outcomes Short Form-36 (SF-36). Multivariate linear regression assessed associations between HRQoL and predictors in cohorts... (More)

OBJECTIVES: To evaluate health-related quality of life (HRQoL) and its determinants in a systemic sclerosis (SSc) multinational inception cohort. We performed a meta-analysis of data from individual countries, and compared the meta-analysis to individual country results by pooling data from each of the countries.

METHODS: SSc patients within 2 years of disease onset were recruited from 5 countries participating in the International Systemic Sclerosis Inception Cohort (INSYNC). Data from each country's database were exported for analysis using a harmonised platform. HRQoL was assessed using the Medical Outcomes Short Form-36 (SF-36). Multivariate linear regression assessed associations between HRQoL and predictors in cohorts separately and meta-analyzed to generate pooled estimates. The analyses were repeated using individual patient data.

RESULTS: Of the 637 SSc patients recruited, the majority was female (80.2%-83.3%), aged between 52.4-56.7 years with limited cutaneous disease subtype (48.6%-66.7%). HRQoL scores were lower for SSc patients than the general population (SF-36 physical component summary (PCS) score (36.4-39.6), mental component summary (MCS) score (41.0-46.4)). Determinants of SF-36 PCS by meta-analysis included increasing age (β=-0.1, 95%CI -0.2, -0.01), diffuse cutaneous disease subtype (β=-8.4, 95%CI -10.6, -6.3), and pulmonary arterial hypertension (β=-10.9, 95%CI -16.6, -5.3). Increasing age (β=0.09, 95%CI 0.0, 0.18) was the only variable associated with SF-36 MCS. Analyses using individual patient data revealed similar results to those of the meta-analysis of cohort data.

CONCLUSIONS: Our study provides estimates of HRQoL in a large inception SSc cohort and provides evidence that individual patient data analysis is valid in the INSYNC dataset.

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Clinical and Experimental Rheumatology
volume
36
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4
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8 pages
publisher
Pacini
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  • scopus:85054356226
  • pmid:30183603
ISSN
0392-856X
language
English
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yes
id
6028eb02-ea72-4f8d-a9fd-7aa8cbbb935a
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http://www.clinexprheumatol.org/abstract.asp?a=12153
date added to LUP
2018-11-06 10:33:02
date last changed
2019-11-27 02:53:36
@article{6028eb02-ea72-4f8d-a9fd-7aa8cbbb935a,
  abstract     = {<p>OBJECTIVES: To evaluate health-related quality of life (HRQoL) and its determinants in a systemic sclerosis (SSc) multinational inception cohort. We performed a meta-analysis of data from individual countries, and compared the meta-analysis to individual country results by pooling data from each of the countries.</p><p>METHODS: SSc patients within 2 years of disease onset were recruited from 5 countries participating in the International Systemic Sclerosis Inception Cohort (INSYNC). Data from each country's database were exported for analysis using a harmonised platform. HRQoL was assessed using the Medical Outcomes Short Form-36 (SF-36). Multivariate linear regression assessed associations between HRQoL and predictors in cohorts separately and meta-analyzed to generate pooled estimates. The analyses were repeated using individual patient data.</p><p>RESULTS: Of the 637 SSc patients recruited, the majority was female (80.2%-83.3%), aged between 52.4-56.7 years with limited cutaneous disease subtype (48.6%-66.7%). HRQoL scores were lower for SSc patients than the general population (SF-36 physical component summary (PCS) score (36.4-39.6), mental component summary (MCS) score (41.0-46.4)). Determinants of SF-36 PCS by meta-analysis included increasing age (β=-0.1, 95%CI -0.2, -0.01), diffuse cutaneous disease subtype (β=-8.4, 95%CI -10.6, -6.3), and pulmonary arterial hypertension (β=-10.9, 95%CI -16.6, -5.3). Increasing age (β=0.09, 95%CI 0.0, 0.18) was the only variable associated with SF-36 MCS. Analyses using individual patient data revealed similar results to those of the meta-analysis of cohort data.</p><p>CONCLUSIONS: Our study provides estimates of HRQoL in a large inception SSc cohort and provides evidence that individual patient data analysis is valid in the INSYNC dataset.</p>},
  author       = {Morrisroe, Kathleen and Hudson, Marie and Baron, Murray and de Vries-Bouwstra, Jeska and Carreira, Patricia E. and Wuttge, Dirk M. and Wang, Mianbo and Frech, Tracy M. and Stevens, Wendy and Proudman, Susanna M. and Nikpour, Mandana},
  issn         = {0392-856X},
  language     = {eng},
  number       = {4},
  pages        = {53--60},
  publisher    = {Pacini},
  series       = {Clinical and Experimental Rheumatology},
  title        = {Determinants of health-related quality of life in a multinational systemic sclerosis inception cohort},
  url          = {http://www.clinexprheumatol.org/abstract.asp?a=12153},
  volume       = {36},
  year         = {2018},
}