Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.
Banke, Elin LU ; Riva, Matteo LU ; Shcherbina, Liliya LU ; Wierup, Nils LU and Degerman, Eva LU
(2013)
In Regulatory Peptides
182(Jan.,11).
p.35-40
- Abstract
- Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide expressed in the nervous system and in endocrine cells, e.g. in pancreatic islets. CART deficient mice exhibit islet dysfunction, impaired insulin secretion and increased body weight. A mutation in the CART gene in humans is associated with reduced metabolic rate, obesity and diabetes. Furthermore, CART is upregulated in islets of type-2 diabetic rats and regulates islet hormone secretion in vitro. While the function of CART in the nervous system has been extensively studied, there is no information on its expression or function in white adipose tissue. CART mRNA and protein were found to be expressed in both subcutaneous and visceral white adipose tissues from... (More)
- Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide expressed in the nervous system and in endocrine cells, e.g. in pancreatic islets. CART deficient mice exhibit islet dysfunction, impaired insulin secretion and increased body weight. A mutation in the CART gene in humans is associated with reduced metabolic rate, obesity and diabetes. Furthermore, CART is upregulated in islets of type-2 diabetic rats and regulates islet hormone secretion in vitro. While the function of CART in the nervous system has been extensively studied, there is no information on its expression or function in white adipose tissue. CART mRNA and protein were found to be expressed in both subcutaneous and visceral white adipose tissues from rat and man. Stimulating rat primary adipocytes with CART significantly potentiated isoprenaline-induced lipolysis, and hormone sensitive lipase activation (phosphorylation of Ser 563). On the other hand, CART significantly potentiated the inhibitory effect of insulin on isoprenaline-induced lipolysis. CART inhibited insulin-induced glucose uptake, which was associated with inhibition of PKB phosphorylation. In conclusion, CART is a novel constituent of human and rat adipocytes and affects several biological processes central in both lipid- and glucose homeostasis. Depending on the surrounding conditions, the effects of CART are insulin-like or insulin-antagonistic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3438729
- author
- Banke, Elin
LU
; Riva, Matteo
LU
; Shcherbina, Liliya
LU
; Wierup, Nils
LU
and Degerman, Eva
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Regulatory Peptides
- volume
- 182
- issue
- Jan.,11
- pages
- 35 - 40
- publisher
- Elsevier
- external identifiers
-
- wos:000317455200006
- pmid:23318496
- scopus:84873958610
- pmid:23318496
- ISSN
- 1873-1686
- DOI
- 10.1016/j.regpep.2012.12.011
- language
- English
- LU publication?
- yes
- id
- 605c1597-9176-43d4-b10c-f8f85517672a (old id 3438729)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23318496?dopt=Abstract
- date added to LUP
- 2016-04-01 10:02:55
- date last changed
- 2022-03-27 04:22:58
@article{605c1597-9176-43d4-b10c-f8f85517672a,
abstract = {{Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide expressed in the nervous system and in endocrine cells, e.g. in pancreatic islets. CART deficient mice exhibit islet dysfunction, impaired insulin secretion and increased body weight. A mutation in the CART gene in humans is associated with reduced metabolic rate, obesity and diabetes. Furthermore, CART is upregulated in islets of type-2 diabetic rats and regulates islet hormone secretion in vitro. While the function of CART in the nervous system has been extensively studied, there is no information on its expression or function in white adipose tissue. CART mRNA and protein were found to be expressed in both subcutaneous and visceral white adipose tissues from rat and man. Stimulating rat primary adipocytes with CART significantly potentiated isoprenaline-induced lipolysis, and hormone sensitive lipase activation (phosphorylation of Ser 563). On the other hand, CART significantly potentiated the inhibitory effect of insulin on isoprenaline-induced lipolysis. CART inhibited insulin-induced glucose uptake, which was associated with inhibition of PKB phosphorylation. In conclusion, CART is a novel constituent of human and rat adipocytes and affects several biological processes central in both lipid- and glucose homeostasis. Depending on the surrounding conditions, the effects of CART are insulin-like or insulin-antagonistic.}},
author = {{Banke, Elin and Riva, Matteo and Shcherbina, Liliya and Wierup, Nils and Degerman, Eva}},
issn = {{1873-1686}},
language = {{eng}},
number = {{Jan.,11}},
pages = {{35--40}},
publisher = {{Elsevier}},
series = {{Regulatory Peptides}},
title = {{Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.}},
url = {{https://lup.lub.lu.se/search/files/1512624/4024141.pdf}},
doi = {{10.1016/j.regpep.2012.12.011}},
volume = {{182}},
year = {{2013}},
}