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Predictors of acute myocardial infarction mortality in hypertensive patients treated in primary care.

Bøg-Hansen, Erik LU ; Larsson, Charlotte A LU ; Gullberg, Bo LU ; Melander, Arne LU ; Bengtsson Boström, Kristina LU ; Råstam, Lennart LU and Lindblad, Ulf LU (2007) In Scandinavian Journal of Primary Health Care 25(4). p.237-243
Abstract
Objective. To explore risk factors for acute myocardial infarction (AMI) mortality in hypertensive patients treated in primary care. Design. Community-based cohort study. Setting. Hypertension outpatient clinic in primary health care. Subjects. Patients who consecutively underwent an annual follow-up during 1992-1993 (n =894; 377 men and 517 women). Methods. All events of fatal AMI were ascertained by record linkage to the National Mortality Register to December 31, 2002. Gender-specific predictors for AMI mortality were analysed by Cox regression. Main outcome measure. AMI mortality. Results. During a mean follow-up of 8.7 years 32 cases (8.5%) of fatal AMI were observed in men and 31 cases (6.0%) were observed in women. Most important... (More)
Objective. To explore risk factors for acute myocardial infarction (AMI) mortality in hypertensive patients treated in primary care. Design. Community-based cohort study. Setting. Hypertension outpatient clinic in primary health care. Subjects. Patients who consecutively underwent an annual follow-up during 1992-1993 (n =894; 377 men and 517 women). Methods. All events of fatal AMI were ascertained by record linkage to the National Mortality Register to December 31, 2002. Gender-specific predictors for AMI mortality were analysed by Cox regression. Main outcome measure. AMI mortality. Results. During a mean follow-up of 8.7 years 32 cases (8.5%) of fatal AMI were observed in men and 31 cases (6.0%) were observed in women. Most important predictors for AMI mortality in men were microalbuminuria (HR 3.8, CI 1.8-8.0) and left ventricular hypertrophy (HR 4.0, CI 1.7-9.4), whilst in women type 2 diabetes (HR 4.8, CI 2.4-9.8) was an important predictor. In hypertensive patients without diabetes male gender was associated with high AMI mortality (HR 2.7, CI 1.4-5.3), but in patients with both hypertension and type 2 diabetes the higher risk in men disappeared (HR 0.8, CI 0.4-1.7). Conclusion. Cardiovascular disease risk factors remain strong predictors of AMI mortality in hypertensive patients but with a different pattern in the two genders. Markers of organ damage are more important predictors in men, whereas markers of impaired glucose metabolism are more important predictors in women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute myocardial infarction, cardiovascular disease risk factors, family practice, hypertension, primary care, type 2 diabetes
in
Scandinavian Journal of Primary Health Care
volume
25
issue
4
pages
237 - 243
publisher
Taylor & Francis
external identifiers
  • wos:000252846800010
  • scopus:36549062990
ISSN
0281-3432
DOI
10.1080/02813430701706253
language
English
LU publication?
yes
id
0821ed6c-8e9f-455c-88f4-4e7b6cf1204f (old id 608249)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17965983&dopt=Abstract
date added to LUP
2008-01-04 11:13:39
date last changed
2017-07-23 03:54:36
@article{0821ed6c-8e9f-455c-88f4-4e7b6cf1204f,
  abstract     = {Objective. To explore risk factors for acute myocardial infarction (AMI) mortality in hypertensive patients treated in primary care. Design. Community-based cohort study. Setting. Hypertension outpatient clinic in primary health care. Subjects. Patients who consecutively underwent an annual follow-up during 1992-1993 (n =894; 377 men and 517 women). Methods. All events of fatal AMI were ascertained by record linkage to the National Mortality Register to December 31, 2002. Gender-specific predictors for AMI mortality were analysed by Cox regression. Main outcome measure. AMI mortality. Results. During a mean follow-up of 8.7 years 32 cases (8.5%) of fatal AMI were observed in men and 31 cases (6.0%) were observed in women. Most important predictors for AMI mortality in men were microalbuminuria (HR 3.8, CI 1.8-8.0) and left ventricular hypertrophy (HR 4.0, CI 1.7-9.4), whilst in women type 2 diabetes (HR 4.8, CI 2.4-9.8) was an important predictor. In hypertensive patients without diabetes male gender was associated with high AMI mortality (HR 2.7, CI 1.4-5.3), but in patients with both hypertension and type 2 diabetes the higher risk in men disappeared (HR 0.8, CI 0.4-1.7). Conclusion. Cardiovascular disease risk factors remain strong predictors of AMI mortality in hypertensive patients but with a different pattern in the two genders. Markers of organ damage are more important predictors in men, whereas markers of impaired glucose metabolism are more important predictors in women.},
  author       = {Bøg-Hansen, Erik and Larsson, Charlotte A and Gullberg, Bo and Melander, Arne and Bengtsson Boström, Kristina and Råstam, Lennart and Lindblad, Ulf},
  issn         = {0281-3432},
  keyword      = {Acute myocardial infarction,cardiovascular disease risk factors,family practice,hypertension,primary care,type 2 diabetes},
  language     = {eng},
  number       = {4},
  pages        = {237--243},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Primary Health Care},
  title        = {Predictors of acute myocardial infarction mortality in hypertensive patients treated in primary care.},
  url          = {http://dx.doi.org/10.1080/02813430701706253},
  volume       = {25},
  year         = {2007},
}