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System for integrated interstitial photodynamic therapy and dosimetric monitoring

Johansson, Ann LU ; Thompson, M; Johansson, T; Bendsöe, Niels LU ; Svanberg, Katarina LU ; Svanberg, Sune LU and Andersson-Engels, Stefan LU (2005) Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV In Proceedings of the SPIE - The International Society for Optical Engineering 5689(1). p.130-140
Abstract
Photodynamic therapy for the treatment of cancer relies on the presence of light, sensitizer and oxygen. By monitoring these three parameters during the treatment a better understanding and treatment control could possibly be achieved. Here we present data from in vivo treatments of solid skin tumors using an instrument for interstitial photodynamic therapy with integrated dosimetric monitoring. By using intra-tumoral ALA-administration and interstitial light delivery solid tumors are targeted. The same fibers are used for measuring the fluence rate at the treatment wavelength, the sensitizer fluorescence and the local blood oxygen saturation during the treatment. The data presented is based on 10 treatments in 8 patients with thick basal... (More)
Photodynamic therapy for the treatment of cancer relies on the presence of light, sensitizer and oxygen. By monitoring these three parameters during the treatment a better understanding and treatment control could possibly be achieved. Here we present data from in vivo treatments of solid skin tumors using an instrument for interstitial photodynamic therapy with integrated dosimetric monitoring. By using intra-tumoral ALA-administration and interstitial light delivery solid tumors are targeted. The same fibers are used for measuring the fluence rate at the treatment wavelength, the sensitizer fluorescence and the local blood oxygen saturation during the treatment. The data presented is based on 10 treatments in 8 patients with thick basal cell carcinomas. The fluence rate measurements at 635 nm indicate a major treatment induced absorption increase, leading to a limited light penetration at the treatment wavelength. This leads to a far from optimal treatment since the absorption increase prevents peripheral tumor regions from being fully treated. An interactive treatment has been implemented assisting the physician in delivering the correct light dose. The absorption increase can be compensated for by either prolonging the treatment time or increasing the output power of each individual treatment fiber. The other parameters of importance, i.e. the sensitizer fluorescence at 705 nm and the local blood oxygen saturation, are monitored in order to get an estimate of the amount of photobleaching and oxygen consumption. Based on the oxygen saturation signal, a fractionized irradiation can be introduced in order to allow for a re-oxygenation of the tissue (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
peripheral tumor region, photodynamic therapy, dosimetric monitoring, integrated interstitial system, 635 nm, cancer, solid skin tumors, sensitizer fluorescence, intra-tumoral ALA-administration, local blood oxygen saturation, basal cell carcinomas, fractionized irradiation, oxygen saturation signal, photobleaching, 705 nm
in
Proceedings of the SPIE - The International Society for Optical Engineering
volume
5689
issue
1
pages
130 - 140
publisher
SPIE
conference name
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV
external identifiers
  • wos:000229038400015
  • scopus:21844459186
ISSN
1996-756X
0277-786X
DOI
10.1117/12.582892
language
English
LU publication?
yes
id
be0b6bea-c581-419d-a44a-b04bafabc14d (old id 615209)
date added to LUP
2007-11-25 12:38:42
date last changed
2017-11-20 15:06:02
@inproceedings{be0b6bea-c581-419d-a44a-b04bafabc14d,
  abstract     = {Photodynamic therapy for the treatment of cancer relies on the presence of light, sensitizer and oxygen. By monitoring these three parameters during the treatment a better understanding and treatment control could possibly be achieved. Here we present data from in vivo treatments of solid skin tumors using an instrument for interstitial photodynamic therapy with integrated dosimetric monitoring. By using intra-tumoral ALA-administration and interstitial light delivery solid tumors are targeted. The same fibers are used for measuring the fluence rate at the treatment wavelength, the sensitizer fluorescence and the local blood oxygen saturation during the treatment. The data presented is based on 10 treatments in 8 patients with thick basal cell carcinomas. The fluence rate measurements at 635 nm indicate a major treatment induced absorption increase, leading to a limited light penetration at the treatment wavelength. This leads to a far from optimal treatment since the absorption increase prevents peripheral tumor regions from being fully treated. An interactive treatment has been implemented assisting the physician in delivering the correct light dose. The absorption increase can be compensated for by either prolonging the treatment time or increasing the output power of each individual treatment fiber. The other parameters of importance, i.e. the sensitizer fluorescence at 705 nm and the local blood oxygen saturation, are monitored in order to get an estimate of the amount of photobleaching and oxygen consumption. Based on the oxygen saturation signal, a fractionized irradiation can be introduced in order to allow for a re-oxygenation of the tissue},
  author       = {Johansson, Ann and Thompson, M and Johansson, T and Bendsöe, Niels and Svanberg, Katarina and Svanberg, Sune and Andersson-Engels, Stefan},
  booktitle    = {Proceedings of the SPIE - The International Society for Optical Engineering},
  issn         = {1996-756X},
  keyword      = {peripheral tumor region,photodynamic therapy,dosimetric monitoring,integrated interstitial system,635 nm,cancer,solid skin tumors,sensitizer fluorescence,intra-tumoral ALA-administration,local blood oxygen saturation,basal cell carcinomas,fractionized irradiation,oxygen saturation signal,photobleaching,705 nm},
  language     = {eng},
  number       = {1},
  pages        = {130--140},
  publisher    = {SPIE},
  title        = {System for integrated interstitial photodynamic therapy and dosimetric monitoring},
  url          = {http://dx.doi.org/10.1117/12.582892},
  volume       = {5689},
  year         = {2005},
}