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Pre-treatment dosimetry for interstitial photodynamic therapy

Johansson, Ann LU ; Hjelm, J; Eriksson, A and Andersson-Engels, Stefan LU (2005) Therapeutic Laser Applications and Laser-Tissue Interactions II In Proceedings of the SPIE - The International Society for Optical Engineering 5863(1). p.1-58630
Abstract
A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that is capable of both delivering the therapeutic irradiation and measuring parameters of relevance to treatment monitoring, knowledge has been gained on temporal variations of tissue light absorption, sensitizer photobleaching and tissue oxygenation status. We speculate on how variations in these three parameters can be implemented in a crude... (More)
A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that is capable of both delivering the therapeutic irradiation and measuring parameters of relevance to treatment monitoring, knowledge has been gained on temporal variations of tissue light absorption, sensitizer photobleaching and tissue oxygenation status. We speculate on how variations in these three parameters can be implemented in a crude pre-treatment dosimetry model for photodynamic therapy (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
tissue oxygenation, sensitizer photobleaching, tissue light absorption, finite element method, genetic algorithm, dosimetry, interstitial photodynamic therapy
in
Proceedings of the SPIE - The International Society for Optical Engineering
volume
5863
issue
1
pages
1 - 58630
publisher
SPIE
conference name
Therapeutic Laser Applications and Laser-Tissue Interactions II
ISSN
0277-786X
1996-756X
DOI
10.1117/12.633089
language
English
LU publication?
yes
id
2618ba75-1aa0-4e81-931d-3358649c4899 (old id 615227)
date added to LUP
2007-11-25 12:35:21
date last changed
2017-11-20 15:06:02
@inproceedings{2618ba75-1aa0-4e81-931d-3358649c4899,
  abstract     = {A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that is capable of both delivering the therapeutic irradiation and measuring parameters of relevance to treatment monitoring, knowledge has been gained on temporal variations of tissue light absorption, sensitizer photobleaching and tissue oxygenation status. We speculate on how variations in these three parameters can be implemented in a crude pre-treatment dosimetry model for photodynamic therapy},
  author       = {Johansson, Ann and Hjelm, J and Eriksson, A and Andersson-Engels, Stefan},
  booktitle    = {Proceedings of the SPIE - The International Society for Optical Engineering},
  issn         = {0277-786X},
  keyword      = {tissue oxygenation,sensitizer photobleaching,tissue light absorption,finite element method,genetic algorithm,dosimetry,interstitial photodynamic therapy},
  language     = {eng},
  number       = {1},
  pages        = {1--58630},
  publisher    = {SPIE},
  title        = {Pre-treatment dosimetry for interstitial photodynamic therapy},
  url          = {http://dx.doi.org/10.1117/12.633089},
  volume       = {5863},
  year         = {2005},
}