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Survival in common cancers defined by risk and survival of family members

Ji, Jianguang LU ; Försti, Asta LU ; Sundquist, Jan LU ; Lenner, Per and Hemminki, Kari LU (2011) In Oncology Reviews 5(1). p.13-20
Abstract

Studies on survival between familial and sporadic cancers have been inconclusive and only recent data on a limited number of cancers are available on the concordance of survival between family members. In this review, we address these questions by evaluating the published and unpublished data from the nation-wide Swedish Family-Cancer Database and a total of 13 cancer sites were assessed. Using sporadic cancer as reference, HRs were close to 1.0 for most of the familial cancers in both the offspring and parental generations, which suggested that survival in patients with familial and sporadic cancers was equal, with an exception for ovarian cancer with a worse prognosis. Compared to offspring whose parents had a poor survival, those... (More)

Studies on survival between familial and sporadic cancers have been inconclusive and only recent data on a limited number of cancers are available on the concordance of survival between family members. In this review, we address these questions by evaluating the published and unpublished data from the nation-wide Swedish Family-Cancer Database and a total of 13 cancer sites were assessed. Using sporadic cancer as reference, HRs were close to 1.0 for most of the familial cancers in both the offspring and parental generations, which suggested that survival in patients with familial and sporadic cancers was equal, with an exception for ovarian cancer with a worse prognosis. Compared to offspring whose parents had a poor survival, those with a good parental survival had a decreased risk of death for most cancers and HR was significantly decreased for cancers in the breast, prostate, bladder, and kidney. For colorectal and nervous system cancers, favorable survival between the generations showed a borderline significance. These data are consistent in showing that both good and poor survival in certain cancers aggregate in families. Genetic factors are likely to contribute to the results. These observations call for intensified efforts to consider heritability in survival as one mechanism regulating prognosis in cancer patients.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Concordance, Familial cancer, Heredity, Heritability of survival
in
Oncology Reviews
volume
5
issue
1
pages
8 pages
publisher
PagePress Publications
external identifiers
  • scopus:79954623870
ISSN
1970-5557
DOI
10.1007/s12156-010-0055-y
language
English
LU publication?
yes
id
61e37443-f7b8-4134-a8c9-18d7912d7813
date added to LUP
2019-03-19 11:15:20
date last changed
2019-03-20 02:15:11
@article{61e37443-f7b8-4134-a8c9-18d7912d7813,
  abstract     = {<p>Studies on survival between familial and sporadic cancers have been inconclusive and only recent data on a limited number of cancers are available on the concordance of survival between family members. In this review, we address these questions by evaluating the published and unpublished data from the nation-wide Swedish Family-Cancer Database and a total of 13 cancer sites were assessed. Using sporadic cancer as reference, HRs were close to 1.0 for most of the familial cancers in both the offspring and parental generations, which suggested that survival in patients with familial and sporadic cancers was equal, with an exception for ovarian cancer with a worse prognosis. Compared to offspring whose parents had a poor survival, those with a good parental survival had a decreased risk of death for most cancers and HR was significantly decreased for cancers in the breast, prostate, bladder, and kidney. For colorectal and nervous system cancers, favorable survival between the generations showed a borderline significance. These data are consistent in showing that both good and poor survival in certain cancers aggregate in families. Genetic factors are likely to contribute to the results. These observations call for intensified efforts to consider heritability in survival as one mechanism regulating prognosis in cancer patients.</p>},
  author       = {Ji, Jianguang and Försti, Asta and Sundquist, Jan and Lenner, Per and Hemminki, Kari},
  issn         = {1970-5557},
  keyword      = {Concordance,Familial cancer,Heredity,Heritability of survival},
  language     = {eng},
  month        = {03},
  number       = {1},
  pages        = {13--20},
  publisher    = {PagePress Publications},
  series       = {Oncology Reviews},
  title        = {Survival in common cancers defined by risk and survival of family members},
  url          = {http://dx.doi.org/10.1007/s12156-010-0055-y},
  volume       = {5},
  year         = {2011},
}