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Neonatal and maternal outcomes comparing women undergoing two in vitro fertilization (IVF) singleton pregnancies and women undergoing one IVF twin pregnancy

Sazonova, Antonina ; Källén, Karin LU ; Thurin-Kjellberg, Ann ; Wennerholm, Ulla-Britt and Bergh, Christina (2013) In Fertility and Sterility 99(3). p.731-737
Abstract
Objective: To compare outcomes for women undergoing two in vitro fertilization (IVF) pregnancies with singletons and women undergoing one IVF twin pregnancy. The concept of single-embryo transfer in IVF has reduced the risks of both maternal and neonatal complications, but there is still a discussion of whether or not twins are a desired outcome of IVF. Design: Registry study. Setting: Not applicable. Patient(s): All reported twins after IVF with double-embryo transfer (n = 1,982) and their mothers (n = 991) and all mothers (n = 921) who gave birth to two IVF singletons (n = 1,842). Intervention(s): None. Main Outcome Measure(s): Maternal and neonatal outcomes including severe neonatal morbidity. Result(s): Preterm birth, very preterm... (More)
Objective: To compare outcomes for women undergoing two in vitro fertilization (IVF) pregnancies with singletons and women undergoing one IVF twin pregnancy. The concept of single-embryo transfer in IVF has reduced the risks of both maternal and neonatal complications, but there is still a discussion of whether or not twins are a desired outcome of IVF. Design: Registry study. Setting: Not applicable. Patient(s): All reported twins after IVF with double-embryo transfer (n = 1,982) and their mothers (n = 991) and all mothers (n = 921) who gave birth to two IVF singletons (n = 1,842). Intervention(s): None. Main Outcome Measure(s): Maternal and neonatal outcomes including severe neonatal morbidity. Result(s): Preterm birth, very preterm birth, low birth weight, very low birth weight, and small for gestational age were dramatically increased for IVF twins compared with two IVF singletons with the same mother, with adjusted odds ratios from 4 to 16. Significantly higher rates of respiratory complications, sepsis, and jaundice were detected among the IVF twins. Significantly higher rates of pre-eclampsia, preterm premature rupture of the membranes, and cesarean section were observed for IVF twin pregnancies. Conclusion(s): The neonatal and maternal outcomes were dramatically better for women undergoing two IVF singleton pregnancies compared with one IVF twin pregnancy after double-embryo transfer. These results support single-embryo transfer to minimize the risks associated with twin pregnancies. (Fertil Steril (R) 2013; 99: 731-7. (C) 2013 by American Society for Reproductive Medicine.) (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IVF/ICSI, maternal outcome, neonatal outcome, singletons, twins
in
Fertility and Sterility
volume
99
issue
3
pages
731 - 737
publisher
Elsevier
external identifiers
  • wos:000315589300024
  • scopus:84875213443
  • pmid:23219009
ISSN
1556-5653
DOI
10.1016/j.fertnstert.2012.11.023
language
English
LU publication?
yes
id
6200b2f1-95bd-4dae-b891-be8c301e0784 (old id 3657213)
date added to LUP
2016-04-01 10:12:48
date last changed
2020-08-05 01:13:29
@article{6200b2f1-95bd-4dae-b891-be8c301e0784,
  abstract     = {Objective: To compare outcomes for women undergoing two in vitro fertilization (IVF) pregnancies with singletons and women undergoing one IVF twin pregnancy. The concept of single-embryo transfer in IVF has reduced the risks of both maternal and neonatal complications, but there is still a discussion of whether or not twins are a desired outcome of IVF. Design: Registry study. Setting: Not applicable. Patient(s): All reported twins after IVF with double-embryo transfer (n = 1,982) and their mothers (n = 991) and all mothers (n = 921) who gave birth to two IVF singletons (n = 1,842). Intervention(s): None. Main Outcome Measure(s): Maternal and neonatal outcomes including severe neonatal morbidity. Result(s): Preterm birth, very preterm birth, low birth weight, very low birth weight, and small for gestational age were dramatically increased for IVF twins compared with two IVF singletons with the same mother, with adjusted odds ratios from 4 to 16. Significantly higher rates of respiratory complications, sepsis, and jaundice were detected among the IVF twins. Significantly higher rates of pre-eclampsia, preterm premature rupture of the membranes, and cesarean section were observed for IVF twin pregnancies. Conclusion(s): The neonatal and maternal outcomes were dramatically better for women undergoing two IVF singleton pregnancies compared with one IVF twin pregnancy after double-embryo transfer. These results support single-embryo transfer to minimize the risks associated with twin pregnancies. (Fertil Steril (R) 2013; 99: 731-7. (C) 2013 by American Society for Reproductive Medicine.)},
  author       = {Sazonova, Antonina and Källén, Karin and Thurin-Kjellberg, Ann and Wennerholm, Ulla-Britt and Bergh, Christina},
  issn         = {1556-5653},
  language     = {eng},
  number       = {3},
  pages        = {731--737},
  publisher    = {Elsevier},
  series       = {Fertility and Sterility},
  title        = {Neonatal and maternal outcomes comparing women undergoing two in vitro fertilization (IVF) singleton pregnancies and women undergoing one IVF twin pregnancy},
  url          = {http://dx.doi.org/10.1016/j.fertnstert.2012.11.023},
  doi          = {10.1016/j.fertnstert.2012.11.023},
  volume       = {99},
  year         = {2013},
}