Advanced

C-Kit signal transduction and involvement in cancer

Lennartsson, Johan; Voytyuk, Olexandr LU ; Heiss, Elke LU ; Sundberg, Christina LU ; Sun, Jianmin LU and Rönnstrand, Lars LU (2005) In Cancer Therapy 3. p.5-28
Abstract
Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce signals from the environment into the cell leading to complex behaviors such as proliferation, migration, survival and differentiation. Many of these behaviors are deregulated in cancer, which is characterized by uncontrolled proliferation, insensitivity

towards death stimuli, migration of tumor cells away from the primary tumor site and in some cases also block of

cellular differentiation leaving the cell in an immature proliferative state. To be able to target these processes it is vital to have a detailed understanding of the receptor function and the downstream pathways activated. In this article we will review the mechanisms by... (More)
Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce signals from the environment into the cell leading to complex behaviors such as proliferation, migration, survival and differentiation. Many of these behaviors are deregulated in cancer, which is characterized by uncontrolled proliferation, insensitivity

towards death stimuli, migration of tumor cells away from the primary tumor site and in some cases also block of

cellular differentiation leaving the cell in an immature proliferative state. To be able to target these processes it is vital to have a detailed understanding of the receptor function and the downstream pathways activated. In this article we will review the mechanisms by which c-Kit induces signal transduction as well as describing tumors in

which c-Kit function is perturbed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fertility, Phospholipase C-g, PI3-kinase, Ras/Erk pathway, degradation, Transcription factors, Adapter proteins, tyrosine kinases, c-Kit signal transduction, Dimerization, Internalization, cancer, Protein tyrosine phosphatases, Hematopoiesis, Gastrointestinal tract, Nervous system, Mastocytosis, Melanoma, Small-cell lung cancer, JAK/STAT pathway, homeostasis, Pigmentation
in
Cancer Therapy
volume
3
pages
5 - 28
publisher
International Society of Cancer Therapy
language
English
LU publication?
yes
id
db016dc3-601f-46a9-8eb9-e9cce6b9bd77 (old id 621260)
alternative location
http://www.cancer-therapy.org/volume3_2005/02_Lennartsson/02._Lennartsson,_5-28.pdf
date added to LUP
2008-06-17 10:33:52
date last changed
2016-09-30 05:54:32
@article{db016dc3-601f-46a9-8eb9-e9cce6b9bd77,
  abstract     = {Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce signals from the environment into the cell leading to complex behaviors such as proliferation, migration, survival and differentiation. Many of these behaviors are deregulated in cancer, which is characterized by uncontrolled proliferation, insensitivity<br/><br>
towards death stimuli, migration of tumor cells away from the primary tumor site and in some cases also block of<br/><br>
cellular differentiation leaving the cell in an immature proliferative state. To be able to target these processes it is vital to have a detailed understanding of the receptor function and the downstream pathways activated. In this article we will review the mechanisms by which c-Kit induces signal transduction as well as describing tumors in<br/><br>
which c-Kit function is perturbed.},
  author       = {Lennartsson, Johan and Voytyuk, Olexandr and Heiss, Elke and Sundberg, Christina and Sun, Jianmin and Rönnstrand, Lars},
  keyword      = {Fertility,Phospholipase C-g,PI3-kinase,Ras/Erk pathway,degradation,Transcription factors,Adapter proteins,tyrosine kinases,c-Kit signal transduction,Dimerization,Internalization,cancer,Protein tyrosine phosphatases,Hematopoiesis,Gastrointestinal tract,Nervous system,Mastocytosis,Melanoma,Small-cell lung cancer,JAK/STAT pathway,homeostasis,Pigmentation},
  language     = {eng},
  pages        = {5--28},
  publisher    = {International Society of Cancer Therapy},
  series       = {Cancer Therapy},
  title        = {C-Kit signal transduction and involvement in cancer},
  volume       = {3},
  year         = {2005},
}