Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate.
(2013) In The FEBS Journal 280(10). p.2431-2446- Abstract
- The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. During pathological conditions such as wound healing, inflammation and cancer iduronic acid has diverse regulatory functions. Iduronic acid is formed by the two epimerases DS-epimerase 1 and DS-epimerase 2 which have different tissue distribution and properties. The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective... (More)
- The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. During pathological conditions such as wound healing, inflammation and cancer iduronic acid has diverse regulatory functions. Iduronic acid is formed by the two epimerases DS-epimerase 1 and DS-epimerase 2 which have different tissue distribution and properties. The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. Future direction of research is to understand the roles of the two epimerases and their interplay with sulfotransferases involved in CS/DS biosynthesis. Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. In this review, we focus on the two enzymes responsible for iduronic acid formation and the role of iduronic acid in health and disease. © 2013 The Authors Journal compilation © 2013 FEBS. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3559429
- author
- Thelin, Martin LU ; Bartolini, Barbara LU ; Axelsson, Jakob H LU ; Gustafsson, Renata LU ; Tykesson, Emil LU ; Pera, Edgar LU ; Oldberg, Åke LU ; Maccarana, Marco LU and Malmström, Anders LU
- organization
-
- Matrix Biology (research group)
- Social Medicine and Health Policy (research group)
- Åke Oldberg´s group (research group)
- Department of Experimental Medical Science
- Stem Cell Center
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The FEBS Journal
- volume
- 280
- issue
- 10
- pages
- 2431 - 2446
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000318701700025
- pmid:23441919
- scopus:84877701739
- pmid:23441919
- ISSN
- 1742-464X
- DOI
- 10.1111/febs.12214
- language
- English
- LU publication?
- yes
- id
- 62a4b529-f9de-44e2-b181-0257b4e53c66 (old id 3559429)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23441919?dopt=Abstract
- date added to LUP
- 2016-04-01 10:24:42
- date last changed
- 2022-07-28 22:44:38
@article{62a4b529-f9de-44e2-b181-0257b4e53c66, abstract = {{The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. During pathological conditions such as wound healing, inflammation and cancer iduronic acid has diverse regulatory functions. Iduronic acid is formed by the two epimerases DS-epimerase 1 and DS-epimerase 2 which have different tissue distribution and properties. The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. Future direction of research is to understand the roles of the two epimerases and their interplay with sulfotransferases involved in CS/DS biosynthesis. Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. In this review, we focus on the two enzymes responsible for iduronic acid formation and the role of iduronic acid in health and disease. © 2013 The Authors Journal compilation © 2013 FEBS.}}, author = {{Thelin, Martin and Bartolini, Barbara and Axelsson, Jakob H and Gustafsson, Renata and Tykesson, Emil and Pera, Edgar and Oldberg, Åke and Maccarana, Marco and Malmström, Anders}}, issn = {{1742-464X}}, language = {{eng}}, number = {{10}}, pages = {{2431--2446}}, publisher = {{Wiley-Blackwell}}, series = {{The FEBS Journal}}, title = {{Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate.}}, url = {{http://dx.doi.org/10.1111/febs.12214}}, doi = {{10.1111/febs.12214}}, volume = {{280}}, year = {{2013}}, }