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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate.

Thelin, Martin LU ; Bartolini, Barbara LU ; Axelsson, Jakob H LU ; Gustafsson, Renata LU ; Tykesson, Emil LU orcid ; Pera, Edgar LU ; Oldberg, Åke LU ; Maccarana, Marco LU and Malmström, Anders LU orcid (2013) In The FEBS Journal 280(10). p.2431-2446
Abstract
The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. During pathological conditions such as wound healing, inflammation and cancer iduronic acid has diverse regulatory functions. Iduronic acid is formed by the two epimerases DS-epimerase 1 and DS-epimerase 2 which have different tissue distribution and properties. The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective... (More)
The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. During pathological conditions such as wound healing, inflammation and cancer iduronic acid has diverse regulatory functions. Iduronic acid is formed by the two epimerases DS-epimerase 1 and DS-epimerase 2 which have different tissue distribution and properties. The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. Future direction of research is to understand the roles of the two epimerases and their interplay with sulfotransferases involved in CS/DS biosynthesis. Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. In this review, we focus on the two enzymes responsible for iduronic acid formation and the role of iduronic acid in health and disease. © 2013 The Authors Journal compilation © 2013 FEBS. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The FEBS Journal
volume
280
issue
10
pages
2431 - 2446
publisher
Wiley-Blackwell
external identifiers
  • wos:000318701700025
  • pmid:23441919
  • scopus:84877701739
  • pmid:23441919
ISSN
1742-464X
DOI
10.1111/febs.12214
language
English
LU publication?
yes
id
62a4b529-f9de-44e2-b181-0257b4e53c66 (old id 3559429)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23441919?dopt=Abstract
date added to LUP
2016-04-01 10:24:42
date last changed
2022-07-28 22:44:38
@article{62a4b529-f9de-44e2-b181-0257b4e53c66,
  abstract     = {{The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. During pathological conditions such as wound healing, inflammation and cancer iduronic acid has diverse regulatory functions. Iduronic acid is formed by the two epimerases DS-epimerase 1 and DS-epimerase 2 which have different tissue distribution and properties. The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. Future direction of research is to understand the roles of the two epimerases and their interplay with sulfotransferases involved in CS/DS biosynthesis. Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. In this review, we focus on the two enzymes responsible for iduronic acid formation and the role of iduronic acid in health and disease. © 2013 The Authors Journal compilation © 2013 FEBS.}},
  author       = {{Thelin, Martin and Bartolini, Barbara and Axelsson, Jakob H and Gustafsson, Renata and Tykesson, Emil and Pera, Edgar and Oldberg, Åke and Maccarana, Marco and Malmström, Anders}},
  issn         = {{1742-464X}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2431--2446}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{The FEBS Journal}},
  title        = {{Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate.}},
  url          = {{http://dx.doi.org/10.1111/febs.12214}},
  doi          = {{10.1111/febs.12214}},
  volume       = {{280}},
  year         = {{2013}},
}