Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.
Lindholm, Eero LU ; Melander, Olle LU
; Almgren, Peter
LU
; Berglund, Göran
LU
; Agardh, Carl-David
LU
; Groop, Leif
LU
and Orho-Melander, Marju
LU
(2006)
In PLoS ONE
1(1).
- Abstract
- BACKGROUND: Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI). AIM: To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality. MATERIALS AND METHODS: Using an allelic discrimination method we genotyped 11,064 individuals from three study populations: 1) 4,432 individuals from the Botnia type 2 diabetes (T2D) study, 2) 1,222 patients with MI and 2,345 control subjects participating in the Malmo Diet and Cancer study and comprising an MI case-control sample, and 3) 3,065 T2D patients from... (More)
- BACKGROUND: Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI). AIM: To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality. MATERIALS AND METHODS: Using an allelic discrimination method we genotyped 11,064 individuals from three study populations: 1) 4,432 individuals from the Botnia type 2 diabetes (T2D) study, 2) 1,222 patients with MI and 2,345 control subjects participating in the Malmo Diet and Cancer study and comprising an MI case-control sample, and 3) 3,065 T2D patients from the Local Swedish Diabetes registry. RESULTS: No association between the -168A-->G polymorphism in MHC2TA and MI was observed. However, in the Botnia cohort the AG/GG genotypes were associated with cardiovascular mortality after MI (1.78 [1.09-2.92], p = 0.02). In addition, the AG/GG genotypes were more common in subjects with MetS (40.1% vs. 36.9%, p = 0.03) and in non-diabetic subjects with microalbuminuria (45.4% vs. 36.5%, p = 0.003) compared to control subjects. CONCLUSIONS: A polymorphism in MHC2TA was associated with cardiovascular mortality and predictors of cardiovascular mortality, microalbuminuria and MetS. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/632900
- author
- Lindholm, Eero
LU
; Melander, Olle
LU
; Almgren, Peter
LU
; Berglund, Göran
LU
; Agardh, Carl-David
LU
; Groop, Leif
LU
and Orho-Melander, Marju
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 1
- issue
- 1
- article number
- 64
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000207443600064
- scopus:50149101695
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0000064
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Internal Medicine Research Unit (013242520), Hypertension and Cardiovascular Disease (013242540), Diabetes and Endocrinology (013241530), Unit on Vascular Diabetic Complications (013241510)
- id
- 64972991-aaa8-4c0b-bd8e-acf7b92ff320 (old id 632900)
- date added to LUP
- 2016-04-01 15:41:30
- date last changed
- 2024-04-11 10:31:22
@article{64972991-aaa8-4c0b-bd8e-acf7b92ff320,
abstract = {{BACKGROUND: Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI). AIM: To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality. MATERIALS AND METHODS: Using an allelic discrimination method we genotyped 11,064 individuals from three study populations: 1) 4,432 individuals from the Botnia type 2 diabetes (T2D) study, 2) 1,222 patients with MI and 2,345 control subjects participating in the Malmo Diet and Cancer study and comprising an MI case-control sample, and 3) 3,065 T2D patients from the Local Swedish Diabetes registry. RESULTS: No association between the -168A-->G polymorphism in MHC2TA and MI was observed. However, in the Botnia cohort the AG/GG genotypes were associated with cardiovascular mortality after MI (1.78 [1.09-2.92], p = 0.02). In addition, the AG/GG genotypes were more common in subjects with MetS (40.1% vs. 36.9%, p = 0.03) and in non-diabetic subjects with microalbuminuria (45.4% vs. 36.5%, p = 0.003) compared to control subjects. CONCLUSIONS: A polymorphism in MHC2TA was associated with cardiovascular mortality and predictors of cardiovascular mortality, microalbuminuria and MetS.}},
author = {{Lindholm, Eero and Melander, Olle and Almgren, Peter and Berglund, Göran and Agardh, Carl-David and Groop, Leif and Orho-Melander, Marju}},
issn = {{1932-6203}},
language = {{eng}},
number = {{1}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.}},
url = {{https://lup.lub.lu.se/search/files/4450202/632929.pdf}},
doi = {{10.1371/journal.pone.0000064}},
volume = {{1}},
year = {{2006}},
}