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Metabolic engineering for pentose utilization in Saccharomyces cerevisiae

Hahn-Hägerdal, Bärbel LU ; Karhumaa, Kaisa LU ; Jeppsson, Marie LU and Gorwa-Grauslund, Marie-Francoise LU (2007) In Advances in Biochemical Engineering/Biotechnology 108. p.147-177
Abstract
The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metabolic engineering strategies directed among others toward sugar transport, initial pentose conversion, the pentose phosphate pathway, and the cellular redox metabolism have been exploited. The directed metabolic engineering approach has often been combined with random approaches including adaptation, mutagenesis, and hybridization. The knowledge... (More)
The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metabolic engineering strategies directed among others toward sugar transport, initial pentose conversion, the pentose phosphate pathway, and the cellular redox metabolism have been exploited. The directed metabolic engineering approach has often been combined with random approaches including adaptation, mutagenesis, and hybridization. The knowledge gained about pentose fermentation in S. cerevisiae is primarily limited to genetically and physiologically well-characterized laboratory strains. The translation of this knowledge to strains performing in an industrial context is discussed. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Advances in Biochemical Engineering/Biotechnology
editor
Olsson, Lisbeth and
volume
108
pages
147 - 177
publisher
Springer
external identifiers
  • wos:000250578300006
  • scopus:34548789083
ISSN
0724-6145
ISBN
978-3-540-73650-9
DOI
10.1007/10_2007_062
language
English
LU publication?
yes
id
6aea0cc6-7db6-4099-b6e4-ca0e8939e001 (old id 636696)
date added to LUP
2007-12-03 10:36:54
date last changed
2017-10-15 04:03:16
@inbook{6aea0cc6-7db6-4099-b6e4-ca0e8939e001,
  abstract     = {The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metabolic engineering strategies directed among others toward sugar transport, initial pentose conversion, the pentose phosphate pathway, and the cellular redox metabolism have been exploited. The directed metabolic engineering approach has often been combined with random approaches including adaptation, mutagenesis, and hybridization. The knowledge gained about pentose fermentation in S. cerevisiae is primarily limited to genetically and physiologically well-characterized laboratory strains. The translation of this knowledge to strains performing in an industrial context is discussed.},
  author       = {Hahn-Hägerdal, Bärbel and Karhumaa, Kaisa and Jeppsson, Marie and Gorwa-Grauslund, Marie-Francoise},
  editor       = {Olsson, Lisbeth},
  isbn         = {978-3-540-73650-9},
  issn         = {0724-6145},
  language     = {eng},
  pages        = {147--177},
  publisher    = {Springer},
  series       = {Advances in Biochemical Engineering/Biotechnology},
  title        = {Metabolic engineering for pentose utilization in Saccharomyces cerevisiae},
  url          = {http://dx.doi.org/10.1007/10_2007_062},
  volume       = {108},
  year         = {2007},
}