Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Karrman, Kristina; Castor, Anders; Behrendtz, Mikael; Forestier, Erik; Olsson, Linda; Ehinger, Mats; Biloglav, Andrea; Fioretos, Thoas; Paulsson, Kajsa; Johansson, Bertil

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Mark

Karrman, Kristina ^LU ; Castor, Anders ^LU

; Behrendtz, Mikael ; Forestier, Erik ; Olsson, Linda ^LU ; Ehinger, Mats ^LU ; Biloglav, Andrea ^LU ; Fioretos, Thoas ^LU ; Paulsson, Kajsa ^LU and Johansson, Bertil ^LU (2015) In Journal of Hematology & Oncology 8(1).

Abstract: Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/5340936

author

Karrman, Kristina ^LU ; Castor, Anders ^LU

; Behrendtz, Mikael ; Forestier, Erik ; Olsson, Linda ^LU ; Ehinger, Mats ^LU ; Biloglav, Andrea ^LU ; Fioretos, Thoas ^LU ; Paulsson, Kajsa ^LU and Johansson, Bertil ^LU

organization

publishing date

2015

type

Contribution to journal

publication status

published

subject

in

Journal of Hematology & Oncology

volume

8

issue

1

article number

42

publisher

BioMed Central (BMC)

external identifiers

pmid:25903014
wos:000353761500001
scopus:84928536653
pmid:25903014

ISSN

1756-8722

DOI

10.1186/s13045-015-0138-0

language

English

LU publication?

yes

additional info

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Paediatrics (Lund) (013002000), Division of Clinical Genetics (013022003)

id

63687d33-786a-4277-967a-f2f4c5da657b (old id 5340936)

alternative location

http://www.ncbi.nlm.nih.gov/pubmed/25903014?dopt=Abstract

date added to LUP

2016-04-01 14:47:19

date last changed

2025-10-14 11:49:36

@article{63687d33-786a-4277-967a-f2f4c5da657b,
  abstract     = {{Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.}},
  author       = {{Karrman, Kristina and Castor, Anders and Behrendtz, Mikael and Forestier, Erik and Olsson, Linda and Ehinger, Mats and Biloglav, Andrea and Fioretos, Thoas and Paulsson, Kajsa and Johansson, Bertil}},
  issn         = {{1756-8722}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Hematology & Oncology}},
  title        = {{Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.}},
  url          = {{https://lup.lub.lu.se/search/files/4166590/8147034}},
  doi          = {{10.1186/s13045-015-0138-0}},
  volume       = {{8}},
  year         = {{2015}},
}

Lund University Publications

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Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.