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Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Karrman, Kristina LU ; Castor, Anders LU ; Behrendtz, Mikael ; Forestier, Erik ; Olsson, Linda LU ; Ehinger, Mats LU ; Biloglav, Andrea LU ; Fioretos, Thoas LU ; Paulsson, Kajsa LU and Johansson, Bertil LU (2015) In Journal of Hematology & Oncology 8(1).
Abstract
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hematology & Oncology
volume
8
issue
1
article number
42
publisher
BioMed Central (BMC)
external identifiers
  • pmid:25903014
  • wos:000353761500001
  • scopus:84928536653
  • pmid:25903014
ISSN
1756-8722
DOI
10.1186/s13045-015-0138-0
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Paediatrics (Lund) (013002000), Division of Clinical Genetics (013022003)
id
63687d33-786a-4277-967a-f2f4c5da657b (old id 5340936)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25903014?dopt=Abstract
date added to LUP
2016-04-01 14:47:19
date last changed
2022-01-28 02:31:19
@article{63687d33-786a-4277-967a-f2f4c5da657b,
  abstract     = {{Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.}},
  author       = {{Karrman, Kristina and Castor, Anders and Behrendtz, Mikael and Forestier, Erik and Olsson, Linda and Ehinger, Mats and Biloglav, Andrea and Fioretos, Thoas and Paulsson, Kajsa and Johansson, Bertil}},
  issn         = {{1756-8722}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Hematology & Oncology}},
  title        = {{Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.}},
  url          = {{https://lup.lub.lu.se/search/files/4166590/8147034}},
  doi          = {{10.1186/s13045-015-0138-0}},
  volume       = {{8}},
  year         = {{2015}},
}