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Interstitial photodynamic therapy for primary prostate cancer incorporating realtime treatment dosimetry

Johansson, Ann LU ; Axelsson, Johan LU ; Swartling, Johannes; Johansson, Thomas; Palsson, Sara; Stensson, Johan; Einarsdottir, Margret; Svanberg, Katarina LU ; Bendsöe, Niels LU and Kalkner, Karl Mikael, et al. (2007) Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI In Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6427. p.4270-4270
Abstract
Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and shortterm response to the therapeutic irradiation. Within our group, an instrument for interstitial PDT on prostate tissue that incorporates realtime treatment feedback is being developed. The treatment protocol consists of two parts. The first part incorporates the pre-treatment plan with ultrasound investigations, providing the geometry for the prostate gland and surrounding risk organs, an iterative... (More)
Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and shortterm response to the therapeutic irradiation. Within our group, an instrument for interstitial PDT on prostate tissue that incorporates realtime treatment feedback is being developed. The treatment protocol consists of two parts. The first part incorporates the pre-treatment plan with ultrasound investigations, providing the geometry for the prostate gland and surrounding risk organs, an iterative random-search algorithm to determine near-optimal fiber positions within the reconstructed geometry and a Block-Cimmino optimization algorithm for predicting individual fiber irradiation times. During the second part, the therapeutic light delivery is combined with measurements of the light transmission signals between the optical fibers, thus monitoring the tissue effective attenuation coefficient by means of spatially resolved spectroscopy. These data are then used as input for repeated runs of the Block-Cimmino optimization algorithm. Thus, the irradiation times for individual fibers are updated throughout the treatment in order to compensate for the influence of changes in tissue composition on the light distribution at the therapeutic wavelength. (Less)
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publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Prostate specific antigen (PSA), Irradiation times, Prostate cancer
in
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
volume
6427
pages
4270 - 4270
publisher
SPIE
conference name
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
external identifiers
  • wos:000246489700016
  • scopus:34548270982
ISSN
1042-4687
1605-7422
DOI
10.1117/12.699903
language
English
LU publication?
yes
id
f7307146-721f-4d41-9c35-2b023c1b1df1 (old id 643374)
date added to LUP
2007-12-04 15:29:43
date last changed
2017-11-20 15:06:01
@inproceedings{f7307146-721f-4d41-9c35-2b023c1b1df1,
  abstract     = {Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and shortterm response to the therapeutic irradiation. Within our group, an instrument for interstitial PDT on prostate tissue that incorporates realtime treatment feedback is being developed. The treatment protocol consists of two parts. The first part incorporates the pre-treatment plan with ultrasound investigations, providing the geometry for the prostate gland and surrounding risk organs, an iterative random-search algorithm to determine near-optimal fiber positions within the reconstructed geometry and a Block-Cimmino optimization algorithm for predicting individual fiber irradiation times. During the second part, the therapeutic light delivery is combined with measurements of the light transmission signals between the optical fibers, thus monitoring the tissue effective attenuation coefficient by means of spatially resolved spectroscopy. These data are then used as input for repeated runs of the Block-Cimmino optimization algorithm. Thus, the irradiation times for individual fibers are updated throughout the treatment in order to compensate for the influence of changes in tissue composition on the light distribution at the therapeutic wavelength.},
  author       = {Johansson, Ann and Axelsson, Johan and Swartling, Johannes and Johansson, Thomas and Palsson, Sara and Stensson, Johan and Einarsdottir, Margret and Svanberg, Katarina and Bendsöe, Niels and Kalkner, Karl Mikael and Nilsson, Sten and Svanberg, Sune and Andersson-Engels, Stefan},
  booktitle    = {Progress in Biomedical Optics and Imaging - Proceedings of SPIE},
  issn         = {1042-4687},
  keyword      = {Prostate specific antigen (PSA),Irradiation times,Prostate cancer},
  language     = {eng},
  pages        = {4270--4270},
  publisher    = {SPIE},
  title        = {Interstitial photodynamic therapy for primary prostate cancer incorporating realtime treatment dosimetry},
  url          = {http://dx.doi.org/10.1117/12.699903},
  volume       = {6427},
  year         = {2007},
}