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Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition

Bengzon, Johan LU ; Okabe, Shigeo ; Lindvall, Olle LU and Mckay, Ronald D. G. (1999) In European Journal of Neuroscience 11(3). p.916-922
Abstract

The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded acid generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor... (More)

The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded acid generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Neuroscience
volume
11
issue
3
pages
916 - 922
publisher
Wiley-Blackwell
external identifiers
  • scopus:0033006628
  • pmid:10103085
ISSN
0953-816X
DOI
10.1046/j.1460-9568.1999.00500.x
language
English
LU publication?
yes
id
6445a929-d8a2-494b-9b54-d19c81321d48
date added to LUP
2019-06-04 16:06:13
date last changed
2024-01-01 09:20:20
@article{6445a929-d8a2-494b-9b54-d19c81321d48,
  abstract     = {{<p>The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded acid generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy.</p>}},
  author       = {{Bengzon, Johan and Okabe, Shigeo and Lindvall, Olle and Mckay, Ronald D. G.}},
  issn         = {{0953-816X}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{916--922}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Neuroscience}},
  title        = {{Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition}},
  url          = {{http://dx.doi.org/10.1046/j.1460-9568.1999.00500.x}},
  doi          = {{10.1046/j.1460-9568.1999.00500.x}},
  volume       = {{11}},
  year         = {{1999}},
}