Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition
(1999) In European Journal of Neuroscience 11(3). p.916-922- Abstract
The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded acid generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor... (More)
The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded acid generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy.
(Less)
- author
- Bengzon, Johan LU ; Okabe, Shigeo ; Lindvall, Olle LU and Mckay, Ronald D. G.
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Neuroscience
- volume
- 11
- issue
- 3
- pages
- 916 - 922
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:10103085
- scopus:0033006628
- ISSN
- 0953-816X
- DOI
- 10.1046/j.1460-9568.1999.00500.x
- language
- English
- LU publication?
- yes
- id
- 6445a929-d8a2-494b-9b54-d19c81321d48
- date added to LUP
- 2019-06-04 16:06:13
- date last changed
- 2024-01-01 09:20:20
@article{6445a929-d8a2-494b-9b54-d19c81321d48, abstract = {{<p>The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded acid generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy.</p>}}, author = {{Bengzon, Johan and Okabe, Shigeo and Lindvall, Olle and Mckay, Ronald D. G.}}, issn = {{0953-816X}}, language = {{eng}}, number = {{3}}, pages = {{916--922}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Neuroscience}}, title = {{Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition}}, url = {{http://dx.doi.org/10.1046/j.1460-9568.1999.00500.x}}, doi = {{10.1046/j.1460-9568.1999.00500.x}}, volume = {{11}}, year = {{1999}}, }