Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Variable interatrial conduction illustrated in a hypertrophic cardiomyopathy population

Holmqvist, Fredrik LU ; Platonov, Pyotr LU ; Carlson, Jonas LU orcid ; Havmöller, Rasmus LU ; Waktare, Johan E. P. ; McKenna, William J. ; Olsson, Bertil LU and Meurling, Carl LU (2007) In Annals of Noninvasive Electrocardiology 12(3). p.227-236
Abstract
Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were... (More)
Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were subsequently transformed to orthogonal lead data, and unfiltered signal-averaged P-wave analysis was performed. The P-wave duration was longer in the HCM patients compared to the controls (149 +/- 22 vs 130 +/- 16 ms, P < 0.0001). Examination of the P-wave morphology demonstrated changes in conduction patterns compatible with interatrial conduction block of varying severity in both groups, but a higher degree of interatrial block seen in the HCM population. These changes were most prominent in the Leads Y and Z. Conclusion: The present study suggests that the longer P-wave duration observed in HCM patients may be explained by a higher prevalence of block in one or more of the interatrial conduction routes. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ECG analysis, noninvasive, hypertrophic cardiomyopathy, atrial fibrillation, signal-averaged
in
Annals of Noninvasive Electrocardiology
volume
12
issue
3
pages
227 - 236
publisher
Wiley-Blackwell
external identifiers
  • wos:000247817000007
  • scopus:34447119528
  • pmid:17617068
ISSN
1082-720X
DOI
10.1111/j.1542-474X.2007.00166.x
language
English
LU publication?
yes
id
5b0fd3b2-f193-4bdb-a3ee-fbde5bedd9bc (old id 645995)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17617068&dopt=Abstract
date added to LUP
2016-04-01 11:35:18
date last changed
2022-01-26 07:20:41
@article{5b0fd3b2-f193-4bdb-a3ee-fbde5bedd9bc,
  abstract     = {{Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were subsequently transformed to orthogonal lead data, and unfiltered signal-averaged P-wave analysis was performed. The P-wave duration was longer in the HCM patients compared to the controls (149 +/- 22 vs 130 +/- 16 ms, P &lt; 0.0001). Examination of the P-wave morphology demonstrated changes in conduction patterns compatible with interatrial conduction block of varying severity in both groups, but a higher degree of interatrial block seen in the HCM population. These changes were most prominent in the Leads Y and Z. Conclusion: The present study suggests that the longer P-wave duration observed in HCM patients may be explained by a higher prevalence of block in one or more of the interatrial conduction routes.}},
  author       = {{Holmqvist, Fredrik and Platonov, Pyotr and Carlson, Jonas and Havmöller, Rasmus and Waktare, Johan E. P. and McKenna, William J. and Olsson, Bertil and Meurling, Carl}},
  issn         = {{1082-720X}},
  keywords     = {{ECG analysis; noninvasive; hypertrophic cardiomyopathy; atrial fibrillation; signal-averaged}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{227--236}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Annals of Noninvasive Electrocardiology}},
  title        = {{Variable interatrial conduction illustrated in a hypertrophic cardiomyopathy population}},
  url          = {{http://dx.doi.org/10.1111/j.1542-474X.2007.00166.x}},
  doi          = {{10.1111/j.1542-474X.2007.00166.x}},
  volume       = {{12}},
  year         = {{2007}},
}