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Variable interatrial conduction illustrated in a hypertrophic cardiomyopathy population

Holmqvist, Fredrik LU ; Platonov, Pyotr LU ; Carlson, Jonas LU ; Havmöller, Rasmus LU ; Waktare, Johan E. P.; McKenna, William J.; Olsson, Bertil LU and Meurling, Carl LU (2007) In Annals of Noninvasive Electrocardiology 12(3). p.227-236
Abstract
Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were... (More)
Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were subsequently transformed to orthogonal lead data, and unfiltered signal-averaged P-wave analysis was performed. The P-wave duration was longer in the HCM patients compared to the controls (149 +/- 22 vs 130 +/- 16 ms, P < 0.0001). Examination of the P-wave morphology demonstrated changes in conduction patterns compatible with interatrial conduction block of varying severity in both groups, but a higher degree of interatrial block seen in the HCM population. These changes were most prominent in the Leads Y and Z. Conclusion: The present study suggests that the longer P-wave duration observed in HCM patients may be explained by a higher prevalence of block in one or more of the interatrial conduction routes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ECG analysis, noninvasive, hypertrophic cardiomyopathy, atrial fibrillation, signal-averaged
in
Annals of Noninvasive Electrocardiology
volume
12
issue
3
pages
227 - 236
publisher
Wiley-Blackwell
external identifiers
  • wos:000247817000007
  • scopus:34447119528
ISSN
1082-720X
DOI
10.1111/j.1542-474X.2007.00166.x
language
English
LU publication?
yes
id
5b0fd3b2-f193-4bdb-a3ee-fbde5bedd9bc (old id 645995)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17617068&dopt=Abstract
date added to LUP
2007-12-12 15:54:01
date last changed
2017-05-21 03:28:31
@article{5b0fd3b2-f193-4bdb-a3ee-fbde5bedd9bc,
  abstract     = {Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were subsequently transformed to orthogonal lead data, and unfiltered signal-averaged P-wave analysis was performed. The P-wave duration was longer in the HCM patients compared to the controls (149 +/- 22 vs 130 +/- 16 ms, P &lt; 0.0001). Examination of the P-wave morphology demonstrated changes in conduction patterns compatible with interatrial conduction block of varying severity in both groups, but a higher degree of interatrial block seen in the HCM population. These changes were most prominent in the Leads Y and Z. Conclusion: The present study suggests that the longer P-wave duration observed in HCM patients may be explained by a higher prevalence of block in one or more of the interatrial conduction routes.},
  author       = {Holmqvist, Fredrik and Platonov, Pyotr and Carlson, Jonas and Havmöller, Rasmus and Waktare, Johan E. P. and McKenna, William J. and Olsson, Bertil and Meurling, Carl},
  issn         = {1082-720X},
  keyword      = {ECG analysis,noninvasive,hypertrophic cardiomyopathy,atrial fibrillation,signal-averaged},
  language     = {eng},
  number       = {3},
  pages        = {227--236},
  publisher    = {Wiley-Blackwell},
  series       = {Annals of Noninvasive Electrocardiology},
  title        = {Variable interatrial conduction illustrated in a hypertrophic cardiomyopathy population},
  url          = {http://dx.doi.org/10.1111/j.1542-474X.2007.00166.x},
  volume       = {12},
  year         = {2007},
}