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Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly

Stomrud, Erik LU ; Hansson, Oskar LU ; Blennow, Kaj; Minthon, Lennart LU and Londos, Elisabet LU (2007) In Dementia and Geriatric Cognitive Disorders 24(2). p.118-124
Abstract
Objective: To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples. Methods: In this study, 57 controls were tested for CSF biomarkers at baseline and then cognitively followed over 3 years. Results: Low levels of baseline beta-amyloid 1 - 42 (A beta 42) were associated with development of subjective memory impairment affecting quality of life (memQoL), with a worse Mini Mental Status Examination score and with inability to live in regular housing at follow-up ( p < 0.05). The combination of baseline A beta 42 and phosphorylated tau (P-tau) was found to predict development of pathological memQoL with a... (More)
Objective: To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples. Methods: In this study, 57 controls were tested for CSF biomarkers at baseline and then cognitively followed over 3 years. Results: Low levels of baseline beta-amyloid 1 - 42 (A beta 42) were associated with development of subjective memory impairment affecting quality of life (memQoL), with a worse Mini Mental Status Examination score and with inability to live in regular housing at follow-up ( p < 0.05). The combination of baseline A beta 42 and phosphorylated tau (P-tau) was found to predict development of pathological memQoL with a sensitivity of 71.4% and a specificity of 75.7 (< 0.01). Conclusion: Low A beta 42 and combined A beta 42 and P-tau predicted subjective cognitive decline in healthy individuals. In summary, this study shows that already in the clinically normal population Alzheimer-disease-related biological signs might be detectable. Copyright (c) 2007 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebrospinal fluid biomarker, mild cognitive, early diagnosis, Alzheimer disease, dementia, impairment, Tau protein, beta-amyloid 42
in
Dementia and Geriatric Cognitive Disorders
volume
24
issue
2
pages
118 - 124
publisher
Karger
external identifiers
  • wos:000247824400008
  • scopus:34447634667
ISSN
1420-8008
DOI
10.1159/000105017
language
English
LU publication?
yes
id
811e5e0c-d45f-4b6c-8793-9554b58df193 (old id 648530)
date added to LUP
2007-12-19 10:49:44
date last changed
2017-11-19 03:36:28
@article{811e5e0c-d45f-4b6c-8793-9554b58df193,
  abstract     = {Objective: To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples. Methods: In this study, 57 controls were tested for CSF biomarkers at baseline and then cognitively followed over 3 years. Results: Low levels of baseline beta-amyloid 1 - 42 (A beta 42) were associated with development of subjective memory impairment affecting quality of life (memQoL), with a worse Mini Mental Status Examination score and with inability to live in regular housing at follow-up ( p &lt; 0.05). The combination of baseline A beta 42 and phosphorylated tau (P-tau) was found to predict development of pathological memQoL with a sensitivity of 71.4% and a specificity of 75.7 (&lt; 0.01). Conclusion: Low A beta 42 and combined A beta 42 and P-tau predicted subjective cognitive decline in healthy individuals. In summary, this study shows that already in the clinically normal population Alzheimer-disease-related biological signs might be detectable. Copyright (c) 2007 S. Karger AG, Basel.},
  author       = {Stomrud, Erik and Hansson, Oskar and Blennow, Kaj and Minthon, Lennart and Londos, Elisabet},
  issn         = {1420-8008},
  keyword      = {cerebrospinal fluid biomarker,mild cognitive,early diagnosis,Alzheimer disease,dementia,impairment,Tau protein,beta-amyloid 42},
  language     = {eng},
  number       = {2},
  pages        = {118--124},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly},
  url          = {http://dx.doi.org/10.1159/000105017},
  volume       = {24},
  year         = {2007},
}