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Real exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs

Pierzynowski, Stefan LU ; Sileikiene, V.; Valverde Piedra, J. L.; Szymanczykc, S.; Gregory, P. C.; Kruszewska, Danuta LU ; Mosenthin, R.; Rzasa, A.; Kowalik, S. and Zabielski, R., et al. (2007) In Livestock Science 108(1-3). p.53-56
Abstract
The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback regulation of pancreatic secretion was found for both duodenal and ileal delivery of pancreatic juice. Pancreatic secretion was unaffected by duodenal delivery of bile and bile salts, while ileal delivery of bile and bile salts lowered it. On the other hand, pancreatic secretion was increased by duodenal loading of commercial non- or activated... (More)
The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback regulation of pancreatic secretion was found for both duodenal and ileal delivery of pancreatic juice. Pancreatic secretion was unaffected by duodenal delivery of bile and bile salts, while ileal delivery of bile and bile salts lowered it. On the other hand, pancreatic secretion was increased by duodenal loading of commercial non- or activated pancreatic enzyme preparations, thus probably recognised as dietary protein. Plasma cholecystokinin (CCK) level was lowered only by duodenal delivery of pancreatic juice. In conclusion, the results prove the existence of negative feedback mechanism regulating pancreatic secretion dependent on the presence of pure pancreatic juice or bile at the ileal level. The mechanism at the duodenal level is exclusively sensitive to pure pancreatic juice. (c) 2007 Elsevier B.V All rights reserved. (Less)
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publication status
published
subject
keywords
ileum, pancreatic secretion, duodenum, ileal brake
in
Livestock Science
volume
108
issue
1-3
pages
53 - 56
publisher
Elsevier
external identifiers
  • wos:000247123100013
  • scopus:34247507732
ISSN
1871-1413
DOI
10.1016/j.livsci.2007.01.031
language
English
LU publication?
yes
id
3f578d44-c116-4175-ada6-3df2f11a5c0e (old id 648756)
date added to LUP
2007-12-19 14:07:42
date last changed
2017-01-01 06:38:37
@article{3f578d44-c116-4175-ada6-3df2f11a5c0e,
  abstract     = {The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback regulation of pancreatic secretion was found for both duodenal and ileal delivery of pancreatic juice. Pancreatic secretion was unaffected by duodenal delivery of bile and bile salts, while ileal delivery of bile and bile salts lowered it. On the other hand, pancreatic secretion was increased by duodenal loading of commercial non- or activated pancreatic enzyme preparations, thus probably recognised as dietary protein. Plasma cholecystokinin (CCK) level was lowered only by duodenal delivery of pancreatic juice. In conclusion, the results prove the existence of negative feedback mechanism regulating pancreatic secretion dependent on the presence of pure pancreatic juice or bile at the ileal level. The mechanism at the duodenal level is exclusively sensitive to pure pancreatic juice. (c) 2007 Elsevier B.V All rights reserved.},
  author       = {Pierzynowski, Stefan and Sileikiene, V. and Valverde Piedra, J. L. and Szymanczykc, S. and Gregory, P. C. and Kruszewska, Danuta and Mosenthin, R. and Rzasa, A. and Kowalik, S. and Zabielski, R. and Weström, Björn},
  issn         = {1871-1413},
  keyword      = {ileum,pancreatic secretion,duodenum,ileal brake},
  language     = {eng},
  number       = {1-3},
  pages        = {53--56},
  publisher    = {Elsevier},
  series       = {Livestock Science},
  title        = {Real exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs},
  url          = {http://dx.doi.org/10.1016/j.livsci.2007.01.031},
  volume       = {108},
  year         = {2007},
}