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Microscopic colitis and reproductive factors related to exposure to estrogens and progesterone.

Roth, Bodil LU ; Manjer, Jonas LU and Ohlsson, Bodil LU (2013) In Drug Target Insights 7(Oct 7). p.53-62
Abstract
Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC as well as between patients and controls. A self-administered questionnaire about parity was completed which included questions surrounding age at first childbirth, menarche and menopause, the use of oral contraceptives, and hormonal replacement therapy. Patients with lymphocytic colitis had children less often compared to those with collagenous colitis (OR = 0.20, 95% CI = 0.05-0.86), however no differences were observed between patients with persistent or transient disease. Patients were less often... (More)
Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC as well as between patients and controls. A self-administered questionnaire about parity was completed which included questions surrounding age at first childbirth, menarche and menopause, the use of oral contraceptives, and hormonal replacement therapy. Patients with lymphocytic colitis had children less often compared to those with collagenous colitis (OR = 0.20, 95% CI = 0.05-0.86), however no differences were observed between patients with persistent or transient disease. Patients were less often older than 15 years of age at menarche (OR = 0.48, 95% CI = 0.26-0.91) and were younger at menopause (OR = 0.30, 95% CI = 0.16-0.56) compared with controls. Thus, no obvious association between factors influencing sex hormone levels and presence of MC could be found. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Target Insights
volume
7
issue
Oct 7
pages
53 - 62
publisher
Libertas Academica
external identifiers
  • pmid:24137050
  • scopus:84885652374
ISSN
1177-3928
DOI
10.4137/DTI.S12889
language
English
LU publication?
yes
id
64d41d88-ad51-4daf-8216-c49007a040f1 (old id 4143184)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24137050?dopt=Abstract
date added to LUP
2013-11-04 23:48:41
date last changed
2019-02-20 06:20:47
@article{64d41d88-ad51-4daf-8216-c49007a040f1,
  abstract     = {Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC as well as between patients and controls. A self-administered questionnaire about parity was completed which included questions surrounding age at first childbirth, menarche and menopause, the use of oral contraceptives, and hormonal replacement therapy. Patients with lymphocytic colitis had children less often compared to those with collagenous colitis (OR = 0.20, 95% CI = 0.05-0.86), however no differences were observed between patients with persistent or transient disease. Patients were less often older than 15 years of age at menarche (OR = 0.48, 95% CI = 0.26-0.91) and were younger at menopause (OR = 0.30, 95% CI = 0.16-0.56) compared with controls. Thus, no obvious association between factors influencing sex hormone levels and presence of MC could be found.},
  author       = {Roth, Bodil and Manjer, Jonas and Ohlsson, Bodil},
  issn         = {1177-3928},
  language     = {eng},
  number       = {Oct 7},
  pages        = {53--62},
  publisher    = {Libertas Academica},
  series       = {Drug Target Insights},
  title        = {Microscopic colitis and reproductive factors related to exposure to estrogens and progesterone.},
  url          = {http://dx.doi.org/10.4137/DTI.S12889},
  volume       = {7},
  year         = {2013},
}