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Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition

Friedenreich, Christine; Cust, Anne; Lahmann, Petra H.; Steindorf, Karen; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Mesrine, Sylvie; Linseisen, Jakob; Rohrmann, Sabine and Pischon, Tobias, et al. (2007) In International Journal of Cancer 121(2). p.347-355
Abstract
The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was,undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI... (More)
The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was,undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI = 0.61-1.27). No clear associations between each type of activity and endometrial cancer risk were found for the total study population combined. Associations were more evident in the stratified results, with premenopausal women who were active versus inactive experiencing a risk of 0.66 (95% CI = 0.38-1.14) overall. Among premenopausal women, for household and recreational activities the risk estimates in the highest as compared with the lowest quartiles were, respectively, 0.48 (95% CI = 0.23-0.99) and 0.78 (95% CI = 0.44-1.39). No effect modification by body mass index, hormone replacement therapy, oral contraceptive use or energy intake was found. This study provides no evidence of a protective effect of increased physical activity in endometrial cancer risk in all women but some support for a benefit among premenopausal women. The relative risk reductions are most apparent for household activities. (Less)
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publication status
published
subject
keywords
etiology, physical activity, endometrial cancer, biologic mechanisms
in
International Journal of Cancer
volume
121
issue
2
pages
347 - 355
publisher
John Wiley & Sons
external identifiers
  • wos:000247155000016
  • scopus:34250313242
ISSN
0020-7136
DOI
10.1002/ijc.22676
language
English
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yes
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6f0c727d-ebe1-45d9-bdf8-80b83a575adb (old id 650957)
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2007-12-07 11:03:46
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2017-08-06 03:33:24
@article{6f0c727d-ebe1-45d9-bdf8-80b83a575adb,
  abstract     = {The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was,undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI = 0.61-1.27). No clear associations between each type of activity and endometrial cancer risk were found for the total study population combined. Associations were more evident in the stratified results, with premenopausal women who were active versus inactive experiencing a risk of 0.66 (95% CI = 0.38-1.14) overall. Among premenopausal women, for household and recreational activities the risk estimates in the highest as compared with the lowest quartiles were, respectively, 0.48 (95% CI = 0.23-0.99) and 0.78 (95% CI = 0.44-1.39). No effect modification by body mass index, hormone replacement therapy, oral contraceptive use or energy intake was found. This study provides no evidence of a protective effect of increased physical activity in endometrial cancer risk in all women but some support for a benefit among premenopausal women. The relative risk reductions are most apparent for household activities.},
  author       = {Friedenreich, Christine and Cust, Anne and Lahmann, Petra H. and Steindorf, Karen and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Mesrine, Sylvie and Linseisen, Jakob and Rohrmann, Sabine and Pischon, Tobias and Schulz, Mandy and Tjonneland, Anne and Johnsen, Nina Fons and Overvad, Kim and Mendez, Michelle and Arguelles, M. V. and Martinez Garcia, Carmen and Larranaga, Nerea and Chirlaque, Maria-Dolores and Ardanaz, Eva and Bingham, Sheila and Khaw, Kay-Tee and Allen, Naomi and Key, Tim and Trichopoulou, Antonia and Dilis, Vardis and Trichopoulos, Dimitrios and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Panico, Salvatore and Vineis, Paolo and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. and Monninkhof, Evelyn and Berglund, Göran and Manjer, Jonas and Slimani, Nadia and Ferrari, Pietro and Kaaks, Rudolf and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {etiology,physical activity,endometrial cancer,biologic mechanisms},
  language     = {eng},
  number       = {2},
  pages        = {347--355},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.22676},
  volume       = {121},
  year         = {2007},
}