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Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition

Jenab, Mazda; Riboli, Elio; Cleveland, Rebecca J.; Norat, Teresa; Rinaldi, Sabina; Nieters, Alexandra; Biessy, Carine; Tjonneland, Ann; Olsen, Anja and Overvad, Kim, et al. (2007) In International Journal of Cancer 121(2). p.368-376
Abstract
Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer... (More)
Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR = 1.56, 95% CI = 1.16-2.09, p(trend) < 0.01), which was slightly attenuated after adjustment for BMI and physical activity (OR = 1.37, 95% CI = 1.00-1.88, p(trend) = 0.10). When stratified by anatomical site, the cancer risk was stronger in the colon (OR 1.67, 95% CI = 1.14-2.46, p(trend) < 0.01) than in the rectum (OR 1.42, 95% CI = 0.90-2.25, p(trend) = 0.35). The cancer risk estimates were not heterogeneous by gender or fasting status. No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk. (C) 2007 Wiley-Liss, Inc. (Less)
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publication status
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keywords
EPIC, C-peptide, insulin, colorectal cancer, IGF
in
International Journal of Cancer
volume
121
issue
2
pages
368 - 376
publisher
John Wiley & Sons
external identifiers
  • wos:000247155000019
  • scopus:34250321324
ISSN
0020-7136
DOI
10.1002/ijc.22697
language
English
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yes
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068d5b01-964c-4927-b1a8-4099a2509d1c (old id 650999)
date added to LUP
2007-12-13 10:34:18
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2017-10-01 03:39:19
@article{068d5b01-964c-4927-b1a8-4099a2509d1c,
  abstract     = {Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR = 1.56, 95% CI = 1.16-2.09, p(trend) &lt; 0.01), which was slightly attenuated after adjustment for BMI and physical activity (OR = 1.37, 95% CI = 1.00-1.88, p(trend) = 0.10). When stratified by anatomical site, the cancer risk was stronger in the colon (OR 1.67, 95% CI = 1.14-2.46, p(trend) &lt; 0.01) than in the rectum (OR 1.42, 95% CI = 0.90-2.25, p(trend) = 0.35). The cancer risk estimates were not heterogeneous by gender or fasting status. No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk. (C) 2007 Wiley-Liss, Inc.},
  author       = {Jenab, Mazda and Riboli, Elio and Cleveland, Rebecca J. and Norat, Teresa and Rinaldi, Sabina and Nieters, Alexandra and Biessy, Carine and Tjonneland, Ann and Olsen, Anja and Overvad, Kim and Gronbaek, Henning and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Linseisen, Jakob and Boeing, Heiner and Pischon, Tobias and Trichopoulos, Dimitrios and Oikonomou, Eleni and Trichopoulou, Antonia and Panico, Salvatore and Vineis, Paolo and Berrino, Franco and Tumino, Rosario and Masala, Giovanna and Peters, Petra H. and van Gils, Carla H. and Bueno-de-Mesquita, H. Bas and Ocke, Marga C. and Lund, Eiliv and Mendez, Michelle A. and Tormo, Maria Jose and Barricarte, Aurelio and Martinez-Garcia, Carmen and Dorronsoro, Miren and Ramon Quiros, Jose and Hallmans, Goran and Palmqvist, Richard and Berglund, Göran and Manjer, Jonas and Key, Timothy and Allen, Naomi E. and Bingham, Sheila and Khaw, Kay-Tee and Cust, Anne and Kaaks, Rudolf},
  issn         = {0020-7136},
  keyword      = {EPIC,C-peptide,insulin,colorectal cancer,IGF},
  language     = {eng},
  number       = {2},
  pages        = {368--376},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.22697},
  volume       = {121},
  year         = {2007},
}