Changes in bone mass associated with obesity and weight loss in humans : Applicability of animal models
Jensen, Vivi F.H. LU ; Mølck, Anne Marie ; Dalgaard, Majken ; McGuigan, Fiona E. LU
and Akesson, Kristina E.
LU
(2021)
In Bone
145.
- Abstract
The implications of obesity and weight loss for human bone health are not well understood. Although the bone changes associated with weight loss are similar in humans and rodents, that is not the case for obesity. In humans, obesity is generally associated with increased bone mass, an outcome which is exacerbated by advanced age and menopause. In rodents, by contrast, bone mass decreases in proportion to severity and duration of obesity, and is influenced by sex, age and mechanical load. Despite these discrepancies, rodents are frequently used to model the situation in humans. In this review, we summarise the existing knowledge of the effects of obesity and weight loss on bone mass in humans and rodents, focusing on the translatability... (More)
The implications of obesity and weight loss for human bone health are not well understood. Although the bone changes associated with weight loss are similar in humans and rodents, that is not the case for obesity. In humans, obesity is generally associated with increased bone mass, an outcome which is exacerbated by advanced age and menopause. In rodents, by contrast, bone mass decreases in proportion to severity and duration of obesity, and is influenced by sex, age and mechanical load. Despite these discrepancies, rodents are frequently used to model the situation in humans. In this review, we summarise the existing knowledge of the effects of obesity and weight loss on bone mass in humans and rodents, focusing on the translatability of findings from animal models. We then describe how animal models should be used to broaden the understanding of the relationship between obesity, weight loss, and skeletal health in humans. Specifically, we highlight the aspects of study design that should be considered to optimise translatability of the rodent models of obesity and weight loss. Notably, the sex, age, and nutritional status of the animals should ideally match those of interest in humans. With these caveats in mind, and depending on the research question asked, our review underscores that animal models can provide valuable information for obesity and weight-management research.
(Less)
- author
- Jensen, Vivi F.H.
LU
; Mølck, Anne Marie
; Dalgaard, Majken
; McGuigan, Fiona E.
LU
and Akesson, Kristina E.
LU
- organization
- publishing date
- 2021-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animal model, Bone, Obesity, Rodent, Translatability, Weight loss
- in
- Bone
- volume
- 145
- article number
- 115781
- publisher
- Elsevier
- external identifiers
-
- scopus:85099242311
- pmid:33285255
- ISSN
- 8756-3282
- DOI
- 10.1016/j.bone.2020.115781
- language
- English
- LU publication?
- yes
- id
- 65349266-9217-4137-8555-574ee6b0c59b
- date added to LUP
- 2021-12-22 10:26:57
- date last changed
- 2024-06-15 23:03:44
@article{65349266-9217-4137-8555-574ee6b0c59b,
abstract = {{<p>The implications of obesity and weight loss for human bone health are not well understood. Although the bone changes associated with weight loss are similar in humans and rodents, that is not the case for obesity. In humans, obesity is generally associated with increased bone mass, an outcome which is exacerbated by advanced age and menopause. In rodents, by contrast, bone mass decreases in proportion to severity and duration of obesity, and is influenced by sex, age and mechanical load. Despite these discrepancies, rodents are frequently used to model the situation in humans. In this review, we summarise the existing knowledge of the effects of obesity and weight loss on bone mass in humans and rodents, focusing on the translatability of findings from animal models. We then describe how animal models should be used to broaden the understanding of the relationship between obesity, weight loss, and skeletal health in humans. Specifically, we highlight the aspects of study design that should be considered to optimise translatability of the rodent models of obesity and weight loss. Notably, the sex, age, and nutritional status of the animals should ideally match those of interest in humans. With these caveats in mind, and depending on the research question asked, our review underscores that animal models can provide valuable information for obesity and weight-management research.</p>}},
author = {{Jensen, Vivi F.H. and Mølck, Anne Marie and Dalgaard, Majken and McGuigan, Fiona E. and Akesson, Kristina E.}},
issn = {{8756-3282}},
keywords = {{Animal model; Bone; Obesity; Rodent; Translatability; Weight loss}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Bone}},
title = {{Changes in bone mass associated with obesity and weight loss in humans : Applicability of animal models}},
url = {{http://dx.doi.org/10.1016/j.bone.2020.115781}},
doi = {{10.1016/j.bone.2020.115781}},
volume = {{145}},
year = {{2021}},
}