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Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study

Eising, Stefanie; Svensson, Jannet; Skogstrand, Kristin; Ramelius, Anita LU ; Lynch, Kristian LU ; Andersen, Paal Skytt; Lernmark, Åke LU ; Hougaard, David M.; Pociot, Flemming and Norgaard-Pedersen, Bent, et al. (2007) In Paediatric and Perinatal Epidemiology 21(6). p.507-517
Abstract
Development of type 1 diabetes mellitus (T1D) may be triggered pre- or perinatally by multiple factors. Identifying new predisposing T1D markers or combinations of markers in a large, well-characterised case-control collection may be important for future T1D prevention. The present work describes the design and feasibility of a large and unselected case-control study, which will define and evaluate prediction criteria for T1D at the time of birth. Danish registries (Biological Specimen Bank for Neonatal Screening, and the National Discharge Registry) made it possible to identify and collect dried blood spots (DBS) from newborns who later developed T1D (cases) born 1981-2002. DBS samples from 2086 cases and two matching control subjects per... (More)
Development of type 1 diabetes mellitus (T1D) may be triggered pre- or perinatally by multiple factors. Identifying new predisposing T1D markers or combinations of markers in a large, well-characterised case-control collection may be important for future T1D prevention. The present work describes the design and feasibility of a large and unselected case-control study, which will define and evaluate prediction criteria for T1D at the time of birth. Danish registries (Biological Specimen Bank for Neonatal Screening, and the National Discharge Registry) made it possible to identify and collect dried blood spots (DBS) from newborns who later developed T1D (cases) born 1981-2002. DBS samples from 2086 cases and two matching control subjects per case were analysed for genetic and immune factors that are associated with T1D: (a) candidate genes (HLA, INS and CTLA4), (b) cytokines and inflammatory markers, (c) islet auto-antibodies (GAD65A, IA-2A). The objective of the study was to define reliable prediction tools for T1D using samples available at the time of birth. In a unique approach, the study linked a large unselected and population-based sample resource to well-ascertained clinical databases and advanced technology. It combined genetic, immunological and demographic data to develop prediction algorithms. It also provided a resource for future studies in which new genetic markers can be included as they are identified. (Less)
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published
subject
keywords
genotyping of candidate genes, type 1 diabetes, dried blood spots, biomarkers, cord blood
in
Paediatric and Perinatal Epidemiology
volume
21
issue
6
pages
507 - 517
publisher
Wiley-Blackwell
external identifiers
  • wos:000250276100007
  • scopus:35348929384
ISSN
0269-5022
DOI
10.1111/j.1365-3016.2007.00846.x
language
English
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yes
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7ff57a37-b80c-44b6-9c79-18202f0f5504 (old id 653952)
date added to LUP
2007-12-10 15:39:44
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2017-10-29 03:34:47
@article{7ff57a37-b80c-44b6-9c79-18202f0f5504,
  abstract     = {Development of type 1 diabetes mellitus (T1D) may be triggered pre- or perinatally by multiple factors. Identifying new predisposing T1D markers or combinations of markers in a large, well-characterised case-control collection may be important for future T1D prevention. The present work describes the design and feasibility of a large and unselected case-control study, which will define and evaluate prediction criteria for T1D at the time of birth. Danish registries (Biological Specimen Bank for Neonatal Screening, and the National Discharge Registry) made it possible to identify and collect dried blood spots (DBS) from newborns who later developed T1D (cases) born 1981-2002. DBS samples from 2086 cases and two matching control subjects per case were analysed for genetic and immune factors that are associated with T1D: (a) candidate genes (HLA, INS and CTLA4), (b) cytokines and inflammatory markers, (c) islet auto-antibodies (GAD65A, IA-2A). The objective of the study was to define reliable prediction tools for T1D using samples available at the time of birth. In a unique approach, the study linked a large unselected and population-based sample resource to well-ascertained clinical databases and advanced technology. It combined genetic, immunological and demographic data to develop prediction algorithms. It also provided a resource for future studies in which new genetic markers can be included as they are identified.},
  author       = {Eising, Stefanie and Svensson, Jannet and Skogstrand, Kristin and Ramelius, Anita and Lynch, Kristian and Andersen, Paal Skytt and Lernmark, Åke and Hougaard, David M. and Pociot, Flemming and Norgaard-Pedersen, Bent and Nerup, Jorn},
  issn         = {0269-5022},
  keyword      = {genotyping of candidate genes,type 1 diabetes,dried blood spots,biomarkers,cord blood},
  language     = {eng},
  number       = {6},
  pages        = {507--517},
  publisher    = {Wiley-Blackwell},
  series       = {Paediatric and Perinatal Epidemiology},
  title        = {Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study},
  url          = {http://dx.doi.org/10.1111/j.1365-3016.2007.00846.x},
  volume       = {21},
  year         = {2007},
}