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Variation in the BMP2 gene: Bone mineral density and ultrasound in young adult and elderly women

McGuigan, Fiona LU ; Larzenius, Emma LU ; Callréus, Mattias LU ; Gerdhem, Paul LU ; Luthman, Holger LU and Åkesson, Kristina LU (2007) In Calcified Tissue International 81(4). p.254-262
Abstract
Bone morphogenetic protein-2 (BMP2) plays a key role in bone formation and maintenance. Studies of polymorphisms within the gene in relation to bone mineral density (BMD) and fracture have been inconsistent. Our aim was to investigate associations between polymorphisms in the BMP2 gene and bone mass, fracture, and quantitative ultrasound (QUS) measures at different stages of skeletal development. Study subjects were participants of two population-based cohorts of Swedish women: the PEAK-25 cohort of young adult women aged 25 years (n = 993) and the OPRA cohort of elderly women aged 75 years (n = 1,001). We analyzed four single-nucleotide polymorphisms (SNPs) across the BMP2 gene including the Ser37Ala SNP previously identified in relation... (More)
Bone morphogenetic protein-2 (BMP2) plays a key role in bone formation and maintenance. Studies of polymorphisms within the gene in relation to bone mineral density (BMD) and fracture have been inconsistent. Our aim was to investigate associations between polymorphisms in the BMP2 gene and bone mass, fracture, and quantitative ultrasound (QUS) measures at different stages of skeletal development. Study subjects were participants of two population-based cohorts of Swedish women: the PEAK-25 cohort of young adult women aged 25 years (n = 993) and the OPRA cohort of elderly women aged 75 years (n = 1,001). We analyzed four single-nucleotide polymorphisms (SNPs) across the BMP2 gene including the Ser37Ala SNP previously identified in relation to BMD, QUS of the calcaneus, and, in the elderly women, fracture. BMP2 gene variations were associated with QUS of bone, independent of BMD, but only in the young women. Even after adjusting for confounding factors, SNP rs235754 in the 3' region of the gene was significantly associated with the ultrasound parameters speed of sound (P = 0.003) and stiffness (P = 0.002). The 5' SNP rs235710 showed trends for QUS parameters (P = 0.02-0.07). No association with BMP2 SNPs was observed in either cohort for either BMD or fracture. While further, more extensive genotyping across the gene is recommended, as we may not have captured all information, our preliminary data suggest that variation in BMP2 may play a previously unidentified role in aspects of bone quality, which may be age- and site-dependent. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fracture, ultrasound, polymorphism, peak bone mass, BMP2
in
Calcified Tissue International
volume
81
issue
4
pages
254 - 262
publisher
Springer
external identifiers
  • wos:000249813400002
  • scopus:34848847248
ISSN
1432-0827
DOI
10.1007/s00223-007-9054-9
language
English
LU publication?
yes
id
6609a97e-4cbd-400d-b9ec-4bea23e9265b (old id 654176)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17726567&dopt=Abstract
date added to LUP
2007-12-15 14:18:24
date last changed
2017-01-01 06:41:04
@article{6609a97e-4cbd-400d-b9ec-4bea23e9265b,
  abstract     = {Bone morphogenetic protein-2 (BMP2) plays a key role in bone formation and maintenance. Studies of polymorphisms within the gene in relation to bone mineral density (BMD) and fracture have been inconsistent. Our aim was to investigate associations between polymorphisms in the BMP2 gene and bone mass, fracture, and quantitative ultrasound (QUS) measures at different stages of skeletal development. Study subjects were participants of two population-based cohorts of Swedish women: the PEAK-25 cohort of young adult women aged 25 years (n = 993) and the OPRA cohort of elderly women aged 75 years (n = 1,001). We analyzed four single-nucleotide polymorphisms (SNPs) across the BMP2 gene including the Ser37Ala SNP previously identified in relation to BMD, QUS of the calcaneus, and, in the elderly women, fracture. BMP2 gene variations were associated with QUS of bone, independent of BMD, but only in the young women. Even after adjusting for confounding factors, SNP rs235754 in the 3' region of the gene was significantly associated with the ultrasound parameters speed of sound (P = 0.003) and stiffness (P = 0.002). The 5' SNP rs235710 showed trends for QUS parameters (P = 0.02-0.07). No association with BMP2 SNPs was observed in either cohort for either BMD or fracture. While further, more extensive genotyping across the gene is recommended, as we may not have captured all information, our preliminary data suggest that variation in BMP2 may play a previously unidentified role in aspects of bone quality, which may be age- and site-dependent.},
  author       = {McGuigan, Fiona and Larzenius, Emma and Callréus, Mattias and Gerdhem, Paul and Luthman, Holger and Åkesson, Kristina},
  issn         = {1432-0827},
  keyword      = {fracture,ultrasound,polymorphism,peak bone mass,BMP2},
  language     = {eng},
  number       = {4},
  pages        = {254--262},
  publisher    = {Springer},
  series       = {Calcified Tissue International},
  title        = {Variation in the BMP2 gene: Bone mineral density and ultrasound in young adult and elderly women},
  url          = {http://dx.doi.org/10.1007/s00223-007-9054-9},
  volume       = {81},
  year         = {2007},
}