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Identification of low-risk tumours in histological high-grade soft tissue sarcomas

Engellau, Jacob LU ; Samuelsson, V.; Anderson, Harald LU ; Bjerkehagen, B.; Rissler, Pehr LU ; Sundby-Hall, K. and Rydholm, Anders LU (2007) In European Journal of Cancer 43(13). p.1927-1934
Abstract
In more than one-third of patients with a histological high-grade malignant soft tissue sarcoma metastasis develops despite local control of the primary tumour. Hence, adjuvant chemotherapy is increasingly used for these relatively chemoresistant tumours which requires improved prognostication to exclude low-risk patients from overtreatment. We assessed the value of stepwise prognostication in a series of 434 histological high-grade STS of the extremity and trunk wall. Vascular invasion was used as the first discriminator whereafter the risk factors tumour necrosis, size (>8 cm) and infiltrating growth pattern were used to discriminate high- and low-risk tumours. We identified a high-risk group with a cumulative incidence of metastasis... (More)
In more than one-third of patients with a histological high-grade malignant soft tissue sarcoma metastasis develops despite local control of the primary tumour. Hence, adjuvant chemotherapy is increasingly used for these relatively chemoresistant tumours which requires improved prognostication to exclude low-risk patients from overtreatment. We assessed the value of stepwise prognostication in a series of 434 histological high-grade STS of the extremity and trunk wall. Vascular invasion was used as the first discriminator whereafter the risk factors tumour necrosis, size (>8 cm) and infiltrating growth pattern were used to discriminate high- and low-risk tumours. We identified a high-risk group with a cumulative incidence of metastasis >0.4 at 5 years, and a low-risk group, comprising half of the tumours, with a cumulative incidence of metastasis <0.15. The model was validated in an independent material of 175 patients. This model improved prognostication in STS and is of value for identifying patients who probably should not receive adjuvant chemotherapy. (C) 2007 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pattern, growth, vascular invasion, soft tissue sarcoma, prognostic factors, size, necrosis
in
European Journal of Cancer
volume
43
issue
13
pages
1927 - 1934
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000250128300017
  • scopus:34548015415
ISSN
1879-0852
DOI
10.1016/j.ejca.2007.05.018
language
English
LU publication?
yes
id
de736d54-462d-4281-8628-cbfe32ba477f (old id 655350)
date added to LUP
2007-12-07 15:33:52
date last changed
2017-08-27 04:02:10
@article{de736d54-462d-4281-8628-cbfe32ba477f,
  abstract     = {In more than one-third of patients with a histological high-grade malignant soft tissue sarcoma metastasis develops despite local control of the primary tumour. Hence, adjuvant chemotherapy is increasingly used for these relatively chemoresistant tumours which requires improved prognostication to exclude low-risk patients from overtreatment. We assessed the value of stepwise prognostication in a series of 434 histological high-grade STS of the extremity and trunk wall. Vascular invasion was used as the first discriminator whereafter the risk factors tumour necrosis, size (&gt;8 cm) and infiltrating growth pattern were used to discriminate high- and low-risk tumours. We identified a high-risk group with a cumulative incidence of metastasis &gt;0.4 at 5 years, and a low-risk group, comprising half of the tumours, with a cumulative incidence of metastasis &lt;0.15. The model was validated in an independent material of 175 patients. This model improved prognostication in STS and is of value for identifying patients who probably should not receive adjuvant chemotherapy. (C) 2007 Elsevier Ltd. All rights reserved.},
  author       = {Engellau, Jacob and Samuelsson, V. and Anderson, Harald and Bjerkehagen, B. and Rissler, Pehr and Sundby-Hall, K. and Rydholm, Anders},
  issn         = {1879-0852},
  keyword      = {pattern,growth,vascular invasion,soft tissue sarcoma,prognostic factors,size,necrosis},
  language     = {eng},
  number       = {13},
  pages        = {1927--1934},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Identification of low-risk tumours in histological high-grade soft tissue sarcomas},
  url          = {http://dx.doi.org/10.1016/j.ejca.2007.05.018},
  volume       = {43},
  year         = {2007},
}