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Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort

Cust, Anne E.; Slimani, Nadia; Kaaks, Rudolf; van Bakel, Marit; Biessy, Carine; Ferrari, Pietro; Laville, Martine; Tjonneland, Anne; Olsen, Anja and Overvad, Kim, et al. (2007) In American Journal of Epidemiology 166(8). p.912-923
Abstract
The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95%... (More)
The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates P-heterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy. (Less)
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published
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keywords
insulin, glycemic index, diet, neoplasms, dietary fiber, endometrial, nutrition assessment, dietary carbohydrates, cohort studies
in
American Journal of Epidemiology
volume
166
issue
8
pages
912 - 923
publisher
Oxford University Press
external identifiers
  • wos:000250143200008
  • scopus:34848886867
ISSN
0002-9262
DOI
10.1093/aje/kwm161
language
English
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yes
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a92525dc-6cab-4457-adda-0ea23b7c4399 (old id 655484)
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2007-12-06 11:42:21
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2017-11-19 03:39:55
@article{a92525dc-6cab-4457-adda-0ea23b7c4399,
  abstract     = {The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates P-heterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.},
  author       = {Cust, Anne E. and Slimani, Nadia and Kaaks, Rudolf and van Bakel, Marit and Biessy, Carine and Ferrari, Pietro and Laville, Martine and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Lajous, Martin and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Linseisen, Jakob and Rohrmann, Sabine and Noethlings, Ute and Boeing, Heiner and Palli, Domenico and Sieri, Sabina and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Skeie, Guri and Engeset, Dagrun and Gram, Inger Torhild and Quiros, J. Ramon and Jakszyn, Paula and Sanchez, Maria Jose and Larranaga, Nerea and Navarro, Carmen and Ardanaz, Eva and Wirfält, Elisabet and Berglund, Göran and Lundin, Eva and Hallmans, Goeran and Bueno-de-Mesquita, H. Bas and Du, Huaidong and Peeters, Petra H. M. and Bingham, Shelia and Khaw, Kay-Tee and Allen, Naomi E. and Key, Timothy J. and Jenab, Mazda and Riboli, Elio},
  issn         = {0002-9262},
  keyword      = {insulin,glycemic index,diet,neoplasms,dietary fiber,endometrial,nutrition assessment,dietary carbohydrates,cohort studies},
  language     = {eng},
  number       = {8},
  pages        = {912--923},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort},
  url          = {http://dx.doi.org/10.1093/aje/kwm161},
  volume       = {166},
  year         = {2007},
}