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Absolute quantification of cerebral blood flow in normal volunteers: Correlation between Xe-133SPECT and dynamic susceptibility contrast MRI

Knutsson, Linda LU ; Börjesson, Siv LU ; Larsson, Elna-Marie; Risberg, Jarl LU ; Gustafson, Lars LU ; Passant, Ulla LU ; Ståhlberg, Freddy LU and Wirestam, Ronnie LU (2007) In Journal of Magnetic Resonance Imaging 26(4). p.913-920
Abstract
Purpose: To compare, absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT. Materials and Methods: CBF was measured in 20 healthy volunteers using DSC-MRI at 3T and Xe-133 SPECT. DSC- MRI was accomplished by gradient-echo EPI and CBF was calculated using a time-shift-insenisitive deconvolution algorithm and regional arterial input functions (AIFs). To improve the reproducibility of AIF registration the time integral was rescaled by use, of a venous output function. In the Xe-133 SPECT experiment, Xe-133 gas was inhaled over 8 minutes and CBF was calculated using a biexponential analysis. Results: The average whole-brain CBF estimates obtained by DSC-MRI and Xe- 133 SPECT... (More)
Purpose: To compare, absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT. Materials and Methods: CBF was measured in 20 healthy volunteers using DSC-MRI at 3T and Xe-133 SPECT. DSC- MRI was accomplished by gradient-echo EPI and CBF was calculated using a time-shift-insenisitive deconvolution algorithm and regional arterial input functions (AIFs). To improve the reproducibility of AIF registration the time integral was rescaled by use, of a venous output function. In the Xe-133 SPECT experiment, Xe-133 gas was inhaled over 8 minutes and CBF was calculated using a biexponential analysis. Results: The average whole-brain CBF estimates obtained by DSC-MRI and Xe- 133 SPECT were 85 +/- 23 mL/(min 100 g) and 40 +/- 8 mL/(min 100 g), respectively (mean +/- SD, n = 20). The linear CBF relationship between the two modalities showed a correlation coefficient of r = 0.76 and was described by the equation CBF(MRI) = 2.4 CBF(Xe) - 7.9 (CBF in units of mL/(min 100 g)). Conclusion: A reasonable positive linear correlation between MRI-based and SPECT-based CBF estimates was observed after AIF time-integral correction. The use of DSC-MRI typically results in overestimated absolute perfusion estimates and the present study indicates that this trend is further enhanced by the use of high magnetic field strength (3T). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
magnetic, cerebral blood flow, dynamic susceptibility contrast, resonance imaging, perfusion, Xe-133SPECT
in
Journal of Magnetic Resonance Imaging
volume
26
issue
4
pages
913 - 920
publisher
John Wiley & Sons
external identifiers
  • wos:000249898800012
  • scopus:35148896028
ISSN
1522-2586
DOI
10.1002/jmri.21093
language
English
LU publication?
yes
id
eccbe016-e9ec-4a58-9f4f-0e5a94649154 (old id 655684)
date added to LUP
2007-12-13 17:12:18
date last changed
2017-01-08 03:58:09
@article{eccbe016-e9ec-4a58-9f4f-0e5a94649154,
  abstract     = {Purpose: To compare, absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT. Materials and Methods: CBF was measured in 20 healthy volunteers using DSC-MRI at 3T and Xe-133 SPECT. DSC- MRI was accomplished by gradient-echo EPI and CBF was calculated using a time-shift-insenisitive deconvolution algorithm and regional arterial input functions (AIFs). To improve the reproducibility of AIF registration the time integral was rescaled by use, of a venous output function. In the Xe-133 SPECT experiment, Xe-133 gas was inhaled over 8 minutes and CBF was calculated using a biexponential analysis. Results: The average whole-brain CBF estimates obtained by DSC-MRI and Xe- 133 SPECT were 85 +/- 23 mL/(min 100 g) and 40 +/- 8 mL/(min 100 g), respectively (mean +/- SD, n = 20). The linear CBF relationship between the two modalities showed a correlation coefficient of r = 0.76 and was described by the equation CBF(MRI) = 2.4 CBF(Xe) - 7.9 (CBF in units of mL/(min 100 g)). Conclusion: A reasonable positive linear correlation between MRI-based and SPECT-based CBF estimates was observed after AIF time-integral correction. The use of DSC-MRI typically results in overestimated absolute perfusion estimates and the present study indicates that this trend is further enhanced by the use of high magnetic field strength (3T).},
  author       = {Knutsson, Linda and Börjesson, Siv and Larsson, Elna-Marie and Risberg, Jarl and Gustafson, Lars and Passant, Ulla and Ståhlberg, Freddy and Wirestam, Ronnie},
  issn         = {1522-2586},
  keyword      = {magnetic,cerebral blood flow,dynamic susceptibility contrast,resonance imaging,perfusion,Xe-133SPECT},
  language     = {eng},
  number       = {4},
  pages        = {913--920},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Absolute quantification of cerebral blood flow in normal volunteers: Correlation between Xe-133SPECT and dynamic susceptibility contrast MRI},
  url          = {http://dx.doi.org/10.1002/jmri.21093},
  volume       = {26},
  year         = {2007},
}