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Tirilazad reduces brain edema after middle cerebral artery ligation in hypertensive rats

Karki, A; Westergren, I LU ; Widner, H LU and Johansson, Barbro LU (1994) In Acta Neurochirurgica, Supplement 60. p.3-310
Abstract

Tirilazad (3 mg/kg i.v.) or vehicle was given 10 min, 3 and 12 hours after ligation of the right middle cerebral artery in male spontaneously hypertensive rats (n = 12 in each group). Brain specific gravity was determined in 23 predetermined cortical regions covering the core and penumbra areas 24 hours after the occlusion. The specific gravity was significantly higher in tirilazad-treated rats than in controls (p < 0.0001). When individual regions of the two groups were compared, the difference was significant in 9 of the 23 samples predominantly, but not exclusively, in the penumbra zone.

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Contribution to journal
publication status
published
subject
keywords
Animals, Brain Edema, Cerebral Infarction, Extracellular Space, Hypertension, Lipid Peroxides, Male, Occipital Lobe, Parietal Lobe, Pregnatrienes, Rats, Rats, Inbred SHR, Specific Gravity, Journal Article, Research Support, Non-U.S. Gov't
in
Acta Neurochirurgica, Supplement
volume
60
pages
3 - 310
publisher
Springer
external identifiers
  • scopus:0028186288
ISSN
0065-1419
language
English
LU publication?
yes
id
6562ab94-6bda-43ed-9c4a-4c9ff22ff9ff
date added to LUP
2017-04-19 18:28:18
date last changed
2017-09-20 14:57:09
@article{6562ab94-6bda-43ed-9c4a-4c9ff22ff9ff,
  abstract     = {<p>Tirilazad (3 mg/kg i.v.) or vehicle was given 10 min, 3 and 12 hours after ligation of the right middle cerebral artery in male spontaneously hypertensive rats (n = 12 in each group). Brain specific gravity was determined in 23 predetermined cortical regions covering the core and penumbra areas 24 hours after the occlusion. The specific gravity was significantly higher in tirilazad-treated rats than in controls (p &lt; 0.0001). When individual regions of the two groups were compared, the difference was significant in 9 of the 23 samples predominantly, but not exclusively, in the penumbra zone.</p>},
  author       = {Karki, A and Westergren, I and Widner, H and Johansson, Barbro},
  issn         = {0065-1419},
  keyword      = {Animals,Brain Edema,Cerebral Infarction,Extracellular Space,Hypertension,Lipid Peroxides,Male,Occipital Lobe,Parietal Lobe,Pregnatrienes,Rats,Rats, Inbred SHR,Specific Gravity,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  pages        = {3--310},
  publisher    = {Springer},
  series       = {Acta Neurochirurgica, Supplement},
  title        = {Tirilazad reduces brain edema after middle cerebral artery ligation in hypertensive rats},
  volume       = {60},
  year         = {1994},
}