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Extinction of conditioned blink responses by cerebello-olivary pathway stimulation

Bengtsson, Fredrik LU ; Jirenhed, Dan-Anders LU ; Svensson, Pär LU and Hesslow, Germund LU (2007) In NeuroReport 18(14). p.1479-1482
Abstract
Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from... (More)
Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from this investigation confirm this. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
extinction, inferior olive, unconditioned stimulus, nucleo-olivary, eyeblink conditioning
in
NeuroReport
volume
18
issue
14
pages
1479 - 1482
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000249479900014
  • scopus:34548087273
ISSN
1473-558X
DOI
10.1097/WNR.0b013e3282e326e8
language
English
LU publication?
yes
id
0675c52b-8dae-4124-9bd0-37e63d3f3bf8 (old id 656447)
date added to LUP
2007-12-05 12:13:44
date last changed
2017-07-23 03:41:12
@article{0675c52b-8dae-4124-9bd0-37e63d3f3bf8,
  abstract     = {Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from this investigation confirm this.},
  author       = {Bengtsson, Fredrik and Jirenhed, Dan-Anders and Svensson, Pär and Hesslow, Germund},
  issn         = {1473-558X},
  keyword      = {extinction,inferior olive,unconditioned stimulus,nucleo-olivary,eyeblink conditioning},
  language     = {eng},
  number       = {14},
  pages        = {1479--1482},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Extinction of conditioned blink responses by cerebello-olivary pathway stimulation},
  url          = {http://dx.doi.org/10.1097/WNR.0b013e3282e326e8},
  volume       = {18},
  year         = {2007},
}