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Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers

Vineis, P.; Veglia, F.; Garte, S.; Malaveille, C.; Matullo, G.; Dunning, A.; Peluso, M.; Airoldi, L.; Overvad, K. and Raaschou-Nielsen, O., et al. (2007) In Annals of Oncology 18(7). p.1230-1242
Abstract
Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase 11 metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval... (More)
Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase 11 metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. (Less)
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Contribution to journal
publication status
published
subject
keywords
bladder cancer, metabolic genes, lung cancer, leukemia, nonsmokers
in
Annals of Oncology
volume
18
issue
7
pages
1230 - 1242
publisher
Oxford University Press
external identifiers
  • wos:000249559600016
  • scopus:34547852268
ISSN
1569-8041
DOI
10.1093/annonc/mdm109
language
English
LU publication?
yes
id
0dc74038-40a2-438b-9b3d-53a2d2296d5a (old id 656775)
date added to LUP
2008-01-03 10:50:29
date last changed
2017-04-16 04:16:32
@article{0dc74038-40a2-438b-9b3d-53a2d2296d5a,
  abstract     = {Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase 11 metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55.},
  author       = {Vineis, P. and Veglia, F. and Garte, S. and Malaveille, C. and Matullo, G. and Dunning, A. and Peluso, M. and Airoldi, L. and Overvad, K. and Raaschou-Nielsen, O. and Clavel-Chapelon, F. and Linseisen, J. P. and Kaaks, R. and Boeing, H. and Trichopoulou, A. and Palli, D. and Crosignani, P. and Tumino, R. and Panico, S. and Bueno-De-Mesquita, H. B. and Peeters, P. H. and Lund, E. and Gonzalez, C. A. and Martinez, C. and Dorronsor, M. and Barricarte, A. and Navarro, C. and Quiros, J. R. and Berglund, Göran and Jarvholm, B. and Day, N. E. and Key, T. J. and Saracci, R. and Riboli, E. and Autrup, H.},
  issn         = {1569-8041},
  keyword      = {bladder cancer,metabolic genes,lung cancer,leukemia,nonsmokers},
  language     = {eng},
  number       = {7},
  pages        = {1230--1242},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers},
  url          = {http://dx.doi.org/10.1093/annonc/mdm109},
  volume       = {18},
  year         = {2007},
}