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Variations in plasma phytoestrogen concentrations in European adults

Peeters, Petra H. M.; Slimani, Nadia; van der Schouw, Yvonne T.; Grace, Philip B.; Navarro, Carmen; Tjonneland, Anne; Olsen, Anja; Clavel-Chapelon, Francoise; Touillaud, Marina and Boutron-Ruault, Marie-Christine, et al. (2007) In Journal of Nutrition 137(5). p.1294-1300
Abstract
Dietary phytoestrogens may play a role in chronic disease occurrence. The aim of our study was to assess the variability of plasma concentrations in European populations. We included 15 geographical regions in 9 European countries (Denmark, France, Germany, Greece, Italy, Spain, Sweden, The Netherlands, and UK) and a 16th region, Oxford, UK, where participants were recruited from among vegans and vegetarians. All subjects were participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma concentrations of 3 isoflavones(daidzein, genistein, and glycitein), 2 metabolites of daidzein [O-desmethylangolensin (O-DMA) and equol] and 2 mammalian lignans enterodiol and enterolactone) were measured in 1414... (More)
Dietary phytoestrogens may play a role in chronic disease occurrence. The aim of our study was to assess the variability of plasma concentrations in European populations. We included 15 geographical regions in 9 European countries (Denmark, France, Germany, Greece, Italy, Spain, Sweden, The Netherlands, and UK) and a 16th region, Oxford, UK, where participants were recruited from among vegans and vegetarians. All subjects were participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma concentrations of 3 isoflavones(daidzein, genistein, and glycitein), 2 metabolites of daidzein [O-desmethylangolensin (O-DMA) and equol] and 2 mammalian lignans enterodiol and enterolactone) were measured in 1414 participants. We computed geometric means for each region and used multivariate regression analysis to assess the influence of region, adjusted for gender, age, BMI, alcohol intake, smoking status, and laboratory batch. Many subjects had concentrations below the detection limit [0.1 mu g/L (0.4 nmol/L)] for glycitein (80%), O-DMA (73%) and equol (62%). Excluding subjects from Oxford, UK, the highest concentrations of isoflavones were in subjects from the Netherlands and Cambridge, UK [2-6 mu g/L (7-24 nmol/L); P < 0.05], whereas concentrations for lignans were highest in Denmark [8 mu g/L (27 nmol/L); P < 0.05]. Isoflavones varied 8-to 13-fold, whereas lignans varied 4-fold. In the vegetarian/vegan cohort of Oxford, concentrations of isoflavones were 5-50 times higher than in nonvegetarian regions. Region was the most important determinant of plasma concentrations for all 7 phytoestrogens. Despite the fact that plasma concentrations of phytoestrogens in Europe were low compared with Asian populations, they varied substantially among subjects from the 16 different regions. (Less)
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@article{d92bc856-259e-4b4a-b8c4-86c336ad238d,
  abstract     = {Dietary phytoestrogens may play a role in chronic disease occurrence. The aim of our study was to assess the variability of plasma concentrations in European populations. We included 15 geographical regions in 9 European countries (Denmark, France, Germany, Greece, Italy, Spain, Sweden, The Netherlands, and UK) and a 16th region, Oxford, UK, where participants were recruited from among vegans and vegetarians. All subjects were participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma concentrations of 3 isoflavones(daidzein, genistein, and glycitein), 2 metabolites of daidzein [O-desmethylangolensin (O-DMA) and equol] and 2 mammalian lignans enterodiol and enterolactone) were measured in 1414 participants. We computed geometric means for each region and used multivariate regression analysis to assess the influence of region, adjusted for gender, age, BMI, alcohol intake, smoking status, and laboratory batch. Many subjects had concentrations below the detection limit [0.1 mu g/L (0.4 nmol/L)] for glycitein (80%), O-DMA (73%) and equol (62%). Excluding subjects from Oxford, UK, the highest concentrations of isoflavones were in subjects from the Netherlands and Cambridge, UK [2-6 mu g/L (7-24 nmol/L); P &lt; 0.05], whereas concentrations for lignans were highest in Denmark [8 mu g/L (27 nmol/L); P &lt; 0.05]. Isoflavones varied 8-to 13-fold, whereas lignans varied 4-fold. In the vegetarian/vegan cohort of Oxford, concentrations of isoflavones were 5-50 times higher than in nonvegetarian regions. Region was the most important determinant of plasma concentrations for all 7 phytoestrogens. Despite the fact that plasma concentrations of phytoestrogens in Europe were low compared with Asian populations, they varied substantially among subjects from the 16 different regions.},
  author       = {Peeters, Petra H. M. and Slimani, Nadia and van der Schouw, Yvonne T. and Grace, Philip B. and Navarro, Carmen and Tjonneland, Anne and Olsen, Anja and Clavel-Chapelon, Francoise and Touillaud, Marina and Boutron-Ruault, Marie-Christine and Jenab, Mazda and Kaaks, Rudolf and Linseisen, Jakob and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Dilis, Vardis and Boeing, Heiner and Weikert, Cornelia and Overvad, Kim and Pala, Valeria and Palli, Domenico and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and Bueno-de-Mesquita, H. Bas and van Giis, Carla H. and Skeie, Guri and Jakszyn, Paula and Hallmans, Goran and Berglund, Göran and Key, Tim J. and Travis, Ruth and Riboli, Elio and Bingham, Sheila A.},
  issn         = {1541-6100},
  language     = {eng},
  number       = {5},
  pages        = {1294--1300},
  publisher    = {American Society for Nutrition},
  series       = {Journal of Nutrition},
  title        = {Variations in plasma phytoestrogen concentrations in European adults},
  volume       = {137},
  year         = {2007},
}