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Evaluation of the dynamic patterns of sFlt−1, PlGF and their ratio in maternal plasma from diagnosis to postpartum as a new tool for preeclampsia management

Lykou, Despoina LU orcid ; Kirk, Mille ; Koulouraki, Sevasti ; Rode, Line ; Andersson, Maria LU ; Hansson, Eva LU ; Erlandsson, Lena LU ; Karampas, Grigorios LU and Hansson, Stefan R. LU orcid (2025) In Hypertension in Pregnancy 44(1).
Abstract

Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) women with PE were included, from which 19, 21 and 35 developed early-onset (EPE), late-onset (LPE) and severe-LPE (SLPE) preeclampsia, respectively. Thirty-five (n = 35) women with normotensive pregnancy (NP) served as the reference group. Results: In all subgroups of PE, PlGF decreased from diagnosis to peripartum. In contrast, sFlt−1 and the... (More)

Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) women with PE were included, from which 19, 21 and 35 developed early-onset (EPE), late-onset (LPE) and severe-LPE (SLPE) preeclampsia, respectively. Thirty-five (n = 35) women with normotensive pregnancy (NP) served as the reference group. Results: In all subgroups of PE, PlGF decreased from diagnosis to peripartum. In contrast, sFlt−1 and the ratio rose in LPE and SLPE subgroups, whereas they remained continuously higher and stable in the EPE subgroup. In all subgroups, postpartum concentrations decreased compared to pregnancy levels. Post-term NP had higher sFlt−1 and ratio, and lower PlGF in comparison to term and late-term NP. Preeclamptic pregnancies complicated with fetal growth restriction (FGR) had continuously higher and stable sFlt−1 concentrations and ratio, and lower PlGF concentrations compared to PE without FGR. Different patterns of the three biomarker trajectories were observed in a case-by-case analysis. Conclusion: Further research is warranted to refine pattern analysis and to integrate trajectories of these biomarkers into clinical practice towards personalized care in preeclampsia management.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarker trajectories, fetal growth restriction, obstetric management, pregnancy hypertension, repeated sampling
in
Hypertension in Pregnancy
volume
44
issue
1
article number
2579976
publisher
Taylor & Francis
external identifiers
  • pmid:41297904
  • scopus:105023217508
ISSN
1064-1955
DOI
10.1080/10641955.2025.2579976
language
English
LU publication?
yes
id
6643c40c-ac5c-4800-ad1f-ecea5e43e771
date added to LUP
2026-02-04 12:08:26
date last changed
2026-02-04 12:09:03
@article{6643c40c-ac5c-4800-ad1f-ecea5e43e771,
  abstract     = {{<p>Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) women with PE were included, from which 19, 21 and 35 developed early-onset (EPE), late-onset (LPE) and severe-LPE (SLPE) preeclampsia, respectively. Thirty-five (n = 35) women with normotensive pregnancy (NP) served as the reference group. Results: In all subgroups of PE, PlGF decreased from diagnosis to peripartum. In contrast, sFlt−1 and the ratio rose in LPE and SLPE subgroups, whereas they remained continuously higher and stable in the EPE subgroup. In all subgroups, postpartum concentrations decreased compared to pregnancy levels. Post-term NP had higher sFlt−1 and ratio, and lower PlGF in comparison to term and late-term NP. Preeclamptic pregnancies complicated with fetal growth restriction (FGR) had continuously higher and stable sFlt−1 concentrations and ratio, and lower PlGF concentrations compared to PE without FGR. Different patterns of the three biomarker trajectories were observed in a case-by-case analysis. Conclusion: Further research is warranted to refine pattern analysis and to integrate trajectories of these biomarkers into clinical practice towards personalized care in preeclampsia management.</p>}},
  author       = {{Lykou, Despoina and Kirk, Mille and Koulouraki, Sevasti and Rode, Line and Andersson, Maria and Hansson, Eva and Erlandsson, Lena and Karampas, Grigorios and Hansson, Stefan R.}},
  issn         = {{1064-1955}},
  keywords     = {{Biomarker trajectories; fetal growth restriction; obstetric management; pregnancy hypertension; repeated sampling}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Taylor & Francis}},
  series       = {{Hypertension in Pregnancy}},
  title        = {{Evaluation of the dynamic patterns of sFlt−1, PlGF and their ratio in maternal plasma from diagnosis to postpartum as a new tool for preeclampsia management}},
  url          = {{http://dx.doi.org/10.1080/10641955.2025.2579976}},
  doi          = {{10.1080/10641955.2025.2579976}},
  volume       = {{44}},
  year         = {{2025}},
}