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Giant-cell tumour of the knee - The condition of the cartilage after treatment by curettage and cementing

Vult von Steyern, Fredrik LU ; Kristiansson, I.; Jonsson, Kjell LU ; Mannfolk, Peter LU ; Heinegård, Dick LU and Rydholm, Anders LU (2007) In Journal of Bone and Joint Surgery 89B(3). p.361-365
Abstract
We reviewed nine patients at a mean period of 11 years ( 6 to 16) after curettage and cementing of a giant-cell tumour around the knee to determine if there were any long-term adverse effects on the cartilage. Plain radiography, MRI, delayed gadolinium-enhanced MRI of the cartilage and measurement of the serum level of cartilage oligomeric matrix protein were carried out. The functional outcome was evaluated using the Lysholm knee score. Each patient was physically active and had returned to their previous occupation. Most participated in recreational sports or exercise. The mean Lysholm knee score was 92 ( 83 to 100). Only one patient was found to have cartilage damage adjacent to the cement. This patient had a history of intra-articular... (More)
We reviewed nine patients at a mean period of 11 years ( 6 to 16) after curettage and cementing of a giant-cell tumour around the knee to determine if there were any long-term adverse effects on the cartilage. Plain radiography, MRI, delayed gadolinium-enhanced MRI of the cartilage and measurement of the serum level of cartilage oligomeric matrix protein were carried out. The functional outcome was evaluated using the Lysholm knee score. Each patient was physically active and had returned to their previous occupation. Most participated in recreational sports or exercise. The mean Lysholm knee score was 92 ( 83 to 100). Only one patient was found to have cartilage damage adjacent to the cement. This patient had a history of intra-articular fracture and local recurrence, leading to degenerative changes. Interpretation of the data obtained from delayed gadolinium-enhanced MRI of the cartilage was difficult, with variation in the T1 values which did not correlate with the clinical or radiological findings. We did not find it helpful in the early diagnosis of degeneration of cartilage. We also found no obvious correlation between the serum cartilage oligomeric matrix protein level and the radiological and MR findings, function, time after surgery and the age of the patient. In summary, we found no evidence that the long-term presence of cement close to the knee joint was associated with the development of degenerative osteoarthritis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Bone and Joint Surgery
volume
89B
issue
3
pages
361 - 365
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • wos:000245810900016
  • scopus:34147175124
ISSN
2044-5377
DOI
10.1302/0301-620X.89B3.18604
language
English
LU publication?
yes
id
b19f0e52-c209-4f35-9150-49584f0ccae0 (old id 664538)
date added to LUP
2007-12-19 09:50:46
date last changed
2017-11-05 03:35:51
@article{b19f0e52-c209-4f35-9150-49584f0ccae0,
  abstract     = {We reviewed nine patients at a mean period of 11 years ( 6 to 16) after curettage and cementing of a giant-cell tumour around the knee to determine if there were any long-term adverse effects on the cartilage. Plain radiography, MRI, delayed gadolinium-enhanced MRI of the cartilage and measurement of the serum level of cartilage oligomeric matrix protein were carried out. The functional outcome was evaluated using the Lysholm knee score. Each patient was physically active and had returned to their previous occupation. Most participated in recreational sports or exercise. The mean Lysholm knee score was 92 ( 83 to 100). Only one patient was found to have cartilage damage adjacent to the cement. This patient had a history of intra-articular fracture and local recurrence, leading to degenerative changes. Interpretation of the data obtained from delayed gadolinium-enhanced MRI of the cartilage was difficult, with variation in the T1 values which did not correlate with the clinical or radiological findings. We did not find it helpful in the early diagnosis of degeneration of cartilage. We also found no obvious correlation between the serum cartilage oligomeric matrix protein level and the radiological and MR findings, function, time after surgery and the age of the patient. In summary, we found no evidence that the long-term presence of cement close to the knee joint was associated with the development of degenerative osteoarthritis.},
  author       = {Vult von Steyern, Fredrik and Kristiansson, I. and Jonsson, Kjell and Mannfolk, Peter and Heinegård, Dick and Rydholm, Anders},
  issn         = {2044-5377},
  language     = {eng},
  number       = {3},
  pages        = {361--365},
  publisher    = {British Editorial Society of Bone & Joint Surgery},
  series       = {Journal of Bone and Joint Surgery},
  title        = {Giant-cell tumour of the knee - The condition of the cartilage after treatment by curettage and cementing},
  url          = {http://dx.doi.org/10.1302/0301-620X.89B3.18604},
  volume       = {89B},
  year         = {2007},
}