Cerebrospinal fluid protein reactions during non-neurological surgery
(2007) In Acta Neurologica Scandinavica 115(4). p.254-259- Abstract
- Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF... (More)
- Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (beta TP) remained unchanged. Conclusins- Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/669970
- author
- Anckarsater, R. ; Vasic, N. ; Jideus, L. ; Kristiansson, M. ; Zetterberg, H. ; Blennow, K. and Anckarsäter, Henrik LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- spinal anaesthesia, stress, inflammation, fluid, cerebrospinal, blood-brain barrier, albumin, beta-2-microglobuline
- in
- Acta Neurologica Scandinavica
- volume
- 115
- issue
- 4
- pages
- 254 - 259
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000245054800006
- scopus:33947391218
- ISSN
- 1600-0404
- DOI
- 10.1111/j.1600-0404.2006.00741.x
- language
- English
- LU publication?
- yes
- id
- 925e81bd-91eb-467e-8272-585cfc930526 (old id 669970)
- date added to LUP
- 2016-04-01 16:27:09
- date last changed
- 2022-02-05 08:21:22
@article{925e81bd-91eb-467e-8272-585cfc930526, abstract = {{Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (beta TP) remained unchanged. Conclusins- Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.}}, author = {{Anckarsater, R. and Vasic, N. and Jideus, L. and Kristiansson, M. and Zetterberg, H. and Blennow, K. and Anckarsäter, Henrik}}, issn = {{1600-0404}}, keywords = {{spinal anaesthesia; stress; inflammation; fluid; cerebrospinal; blood-brain barrier; albumin; beta-2-microglobuline}}, language = {{eng}}, number = {{4}}, pages = {{254--259}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Neurologica Scandinavica}}, title = {{Cerebrospinal fluid protein reactions during non-neurological surgery}}, url = {{http://dx.doi.org/10.1111/j.1600-0404.2006.00741.x}}, doi = {{10.1111/j.1600-0404.2006.00741.x}}, volume = {{115}}, year = {{2007}}, }