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Cerebrospinal fluid protein reactions during non-neurological surgery

Anckarsater, R.; Vasic, N.; Jideus, L.; Kristiansson, M.; Zetterberg, H.; Blennow, K. and Anckarsäter, Henrik LU (2007) In Acta Neurologica Scandinavica 115(4). p.254-259
Abstract
Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF... (More)
Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (beta TP) remained unchanged. Conclusins- Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
spinal anaesthesia, stress, inflammation, fluid, cerebrospinal, blood-brain barrier, albumin, beta-2-microglobuline
in
Acta Neurologica Scandinavica
volume
115
issue
4
pages
254 - 259
publisher
Wiley-Blackwell
external identifiers
  • wos:000245054800006
  • scopus:33947391218
ISSN
1600-0404
DOI
10.1111/j.1600-0404.2006.00741.x
language
English
LU publication?
yes
id
925e81bd-91eb-467e-8272-585cfc930526 (old id 669970)
date added to LUP
2007-12-05 09:46:07
date last changed
2017-04-09 04:20:24
@article{925e81bd-91eb-467e-8272-585cfc930526,
  abstract     = {Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (beta TP) remained unchanged. Conclusins- Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.},
  author       = {Anckarsater, R. and Vasic, N. and Jideus, L. and Kristiansson, M. and Zetterberg, H. and Blennow, K. and Anckarsäter, Henrik},
  issn         = {1600-0404},
  keyword      = {spinal anaesthesia,stress,inflammation,fluid,cerebrospinal,blood-brain barrier,albumin,beta-2-microglobuline},
  language     = {eng},
  number       = {4},
  pages        = {254--259},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Neurologica Scandinavica},
  title        = {Cerebrospinal fluid protein reactions during non-neurological surgery},
  url          = {http://dx.doi.org/10.1111/j.1600-0404.2006.00741.x},
  volume       = {115},
  year         = {2007},
}