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Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition

Friedenreich, Christine; Cust, Anne; Lahmann, Petra H.; Steindorf, Karen; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Mesrine, Sylvie; Linseisen, Jakob; Rohrmann, Sabine and Boeing, Heiner, et al. (2007) In Cancer Causes and Control 18(4). p.399-413
Abstract
Objective To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. Methods Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. Results Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI >=... (More)
Objective To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. Methods Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. Results Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI >= 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of >= 88 cm vs. < 80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of >= 20 kg compared with stable weight (+/- 3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users. Conclusion Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy. (Less)
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publication status
published
subject
keywords
mechanisms, adiposity, obesity, risk factors, etiology, anthropometry, endometrial cancer, hormone replacement therapy
in
Cancer Causes and Control
volume
18
issue
4
pages
399 - 413
publisher
Springer
external identifiers
  • wos:000244993900007
  • scopus:33947288101
ISSN
1573-7225
DOI
10.1007/s10552-006-0113-8
language
English
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yes
id
0c55055e-640f-46c8-9ff7-984d7cada5d8 (old id 670234)
date added to LUP
2007-12-07 11:07:15
date last changed
2017-08-20 03:49:05
@article{0c55055e-640f-46c8-9ff7-984d7cada5d8,
  abstract     = {Objective To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. Methods Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. Results Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- &lt; 40 kg/m(2)) compared to normal weight (BMI &lt; 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI &gt;= 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of &gt;= 88 cm vs. &lt; 80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of &gt;= 20 kg compared with stable weight (+/- 3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users. Conclusion Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.},
  author       = {Friedenreich, Christine and Cust, Anne and Lahmann, Petra H. and Steindorf, Karen and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Mesrine, Sylvie and Linseisen, Jakob and Rohrmann, Sabine and Boeing, Heiner and Pischon, Tobias and Tjonneland, Anne and Halkjaer, Jytte and Overvad, Kim and Mendez, Michelle and Redondo, M. L. and Martinez Garcia, Carmen and Larranaga, Nerea and Tormo, Maria-Jose and Gurrea, Aurelio Barricarte and Bingham, Sheila and Khaw, Kay-Tee and Allen, Naomi and Key, Tim and Trichopoulou, Antonia and Vasilopoulou, Effie and Trichopoulos, Dimitrios and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Mattiello, Amalia and Vineis, Paolo and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. and Berglund, Göran and Manjer, Jonas and Lundin, Eva and Lukanova, Annekatrin and Slimani, Nadia and Jenab, Mazda and Kaaks, Rudolf and Riboli, Elio},
  issn         = {1573-7225},
  keyword      = {mechanisms,adiposity,obesity,risk factors,etiology,anthropometry,endometrial cancer,hormone replacement therapy},
  language     = {eng},
  number       = {4},
  pages        = {399--413},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1007/s10552-006-0113-8},
  volume       = {18},
  year         = {2007},
}