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Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution

Lafitte, Géraldine LU ; Thuresson, Krister LU and Söderman, Olle LU (2007) In Journal of Pharmaceutical Sciences 96(2). p.258-263
Abstract
Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel... (More)
Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel are dependent on their size and physicochemical properties. In addition, we show that mucin gel acts as an efficient selective barrier. It favors the disintegration of mixed micelles of nonionic and cationic surfactants by stopping the diffusion of cationic surfactants with slightly affecting the diffusion of the nonionic surfactants. (c) 2006 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diffusion, glycoproteins, mucin gel, imaging methods, NMR, transport, drug
in
Journal of Pharmaceutical Sciences
volume
96
issue
2
pages
258 - 263
publisher
John Wiley & Sons
external identifiers
  • wos:000243957600003
  • scopus:33847656731
ISSN
0022-3549
DOI
10.1002/jps.20749
language
English
LU publication?
yes
id
d3110e3c-5675-4b3d-8dec-d71fd0b6de08 (old id 675135)
date added to LUP
2007-12-13 18:30:16
date last changed
2017-09-10 03:38:25
@article{d3110e3c-5675-4b3d-8dec-d71fd0b6de08,
  abstract     = {Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel are dependent on their size and physicochemical properties. In addition, we show that mucin gel acts as an efficient selective barrier. It favors the disintegration of mixed micelles of nonionic and cationic surfactants by stopping the diffusion of cationic surfactants with slightly affecting the diffusion of the nonionic surfactants. (c) 2006 Wiley-Liss, Inc.},
  author       = {Lafitte, Géraldine and Thuresson, Krister and Söderman, Olle},
  issn         = {0022-3549},
  keyword      = {diffusion,glycoproteins,mucin gel,imaging methods,NMR,transport,drug},
  language     = {eng},
  number       = {2},
  pages        = {258--263},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pharmaceutical Sciences},
  title        = {Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution},
  url          = {http://dx.doi.org/10.1002/jps.20749},
  volume       = {96},
  year         = {2007},
}