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No evidence of association between genetic variants of the PDCD1 ligands and SLE

Abelson, A. K.; Johansson, C. M.; Kozyrev, S. V.; Kristjansdottir, H.; Gunnarsson, I.; Svenungsson, E.; Jönsen, Andreas LU ; Lima, G.; Scherbarth, H. R. and Gamron, S., et al. (2007) In Genes and Immunity 8(1). p.69-74
Abstract
PDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z = 2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N = 149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N = 90), as well as independent sets of patients and controls... (More)
PDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z = 2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N = 149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N = 90), as well as independent sets of patients and controls from Sweden (152 patients, 448 controls) and Argentina (288 patients, 288 controls). We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE. (Less)
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Contribution to journal
publication status
published
subject
keywords
systemic lupus erythematosus, genetic association, linkage disequilibrium, autoimmunity, PD-L1, PD-L2
in
Genes and Immunity
volume
8
issue
1
pages
69 - 74
publisher
Nature Publishing Group
external identifiers
  • wos:000243783500009
  • scopus:33846467725
ISSN
1476-5470
DOI
10.1038/sj.gene.6364360
language
English
LU publication?
yes
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5beea8dd-4dd2-4aa9-bbbf-d90cd0916e60 (old id 676295)
date added to LUP
2008-04-25 13:40:02
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2017-04-09 03:29:40
@article{5beea8dd-4dd2-4aa9-bbbf-d90cd0916e60,
  abstract     = {PDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z = 2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N = 149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N = 90), as well as independent sets of patients and controls from Sweden (152 patients, 448 controls) and Argentina (288 patients, 288 controls). We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE.},
  author       = {Abelson, A. K. and Johansson, C. M. and Kozyrev, S. V. and Kristjansdottir, H. and Gunnarsson, I. and Svenungsson, E. and Jönsen, Andreas and Lima, G. and Scherbarth, H. R. and Gamron, S. and Allievi, A. and Palatnik, S. A. and Alvarellos, A. and Paira, S. and Graf, C. and Guilleron, C. and Catoggio, L. J. and Prigione, C. and Battagliotti, C. G. and Berbotto, G. A. and Garcia, Ma and Perandones, C. E. and Truedsson, L. and Steinsson, K. and Sturfelt, Gunnar and Pons-Estel, B. and Grp, Argentinean Collaborative and Alarcon-Riquelme, M. E.},
  issn         = {1476-5470},
  keyword      = {systemic lupus erythematosus,genetic association,linkage disequilibrium,autoimmunity,PD-L1,PD-L2},
  language     = {eng},
  number       = {1},
  pages        = {69--74},
  publisher    = {Nature Publishing Group},
  series       = {Genes and Immunity},
  title        = {No evidence of association between genetic variants of the PDCD1 ligands and SLE},
  url          = {http://dx.doi.org/10.1038/sj.gene.6364360},
  volume       = {8},
  year         = {2007},
}