Molecular Pathways in the Progression of Hormone-Independent and Metastatic Prostate Cancer
Wegiel, Barbara LU ; Evans Axelsson, Susan LU
; Hellsten, Rebecka
LU
; Otterbein, L. E.
; Bjartell, Anders
LU
and Persson, J. L.
(2010)
In Current Cancer Drug Targets
10(4).
p.392-401
- Abstract
- Once prostate cancer becomes castration resistant, cancer cells may rapidly gain the ability to invade and to metastasize to lymph nodes and distant organs. The progression through hormone-dependent to hormone-independent/castration-resistant and metastatic PCa is poorly understood. In this review paper, we provide an overview on the cellular and molecular mechanisms underlying the process of tumor cell invasion and metastasis in prostate cancer. We specifically presented the most recent findings on the role of multiple cellular signaling pathways including androgen receptor (AR), mitogen-activated protein kinases (MAPK), Akt, transforming growth factor beta (TGF beta), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in... (More)
- Once prostate cancer becomes castration resistant, cancer cells may rapidly gain the ability to invade and to metastasize to lymph nodes and distant organs. The progression through hormone-dependent to hormone-independent/castration-resistant and metastatic PCa is poorly understood. In this review paper, we provide an overview on the cellular and molecular mechanisms underlying the process of tumor cell invasion and metastasis in prostate cancer. We specifically presented the most recent findings on the role of multiple cellular signaling pathways including androgen receptor (AR), mitogen-activated protein kinases (MAPK), Akt, transforming growth factor beta (TGF beta), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in the development of hormone-independent/castration-resistant prostate cancer. In addition, we also discussed the recent findings on signatures of gene expression during prostate cancer progression. Our overviews on the novel findings will help to gain better understanding of the complexity of molecular mechanisms that may play an essential role for the development of castration-resistant and metastatic prostate cancer. It will also shed light on the identifying specific targets and design effective therapeutic drug candidates. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1657523
- author
- Wegiel, Barbara
LU
; Evans Axelsson, Susan
LU
; Hellsten, Rebecka
LU
; Otterbein, L. E.
; Bjartell, Anders
LU
and Persson, J. L.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- castration, molecular pathways, Prostate cancer, androgen receptor, resistance
- in
- Current Cancer Drug Targets
- volume
- 10
- issue
- 4
- pages
- 392 - 401
- publisher
- Bentham Science Publishers
- external identifiers
-
- wos:000279868900004
- scopus:77953682204
- ISSN
- 1873-5576
- language
- English
- LU publication?
- yes
- id
- 67835a40-ecde-45bc-b5b0-a27d1616ba0a (old id 1657523)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20384583
- date added to LUP
- 2016-04-01 10:11:17
- date last changed
- 2022-01-25 20:42:34
@article{67835a40-ecde-45bc-b5b0-a27d1616ba0a,
abstract = {{Once prostate cancer becomes castration resistant, cancer cells may rapidly gain the ability to invade and to metastasize to lymph nodes and distant organs. The progression through hormone-dependent to hormone-independent/castration-resistant and metastatic PCa is poorly understood. In this review paper, we provide an overview on the cellular and molecular mechanisms underlying the process of tumor cell invasion and metastasis in prostate cancer. We specifically presented the most recent findings on the role of multiple cellular signaling pathways including androgen receptor (AR), mitogen-activated protein kinases (MAPK), Akt, transforming growth factor beta (TGF beta), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in the development of hormone-independent/castration-resistant prostate cancer. In addition, we also discussed the recent findings on signatures of gene expression during prostate cancer progression. Our overviews on the novel findings will help to gain better understanding of the complexity of molecular mechanisms that may play an essential role for the development of castration-resistant and metastatic prostate cancer. It will also shed light on the identifying specific targets and design effective therapeutic drug candidates.}},
author = {{Wegiel, Barbara and Evans Axelsson, Susan and Hellsten, Rebecka and Otterbein, L. E. and Bjartell, Anders and Persson, J. L.}},
issn = {{1873-5576}},
keywords = {{castration; molecular pathways; Prostate cancer; androgen receptor; resistance}},
language = {{eng}},
number = {{4}},
pages = {{392--401}},
publisher = {{Bentham Science Publishers}},
series = {{Current Cancer Drug Targets}},
title = {{Molecular Pathways in the Progression of Hormone-Independent and Metastatic Prostate Cancer}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/20384583}},
volume = {{10}},
year = {{2010}},
}