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TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial

Hagopian, William A. ; Lernmark, Åke LU orcid ; Rewers, Marian J. ; Simell, Olli G. ; She, Jin-Xiong ; Ziegler, Anette G. ; Krischer, Jeffrey P. and Akolkar, Beena (2006) In Annals of the New York Academy of Sciences 1079. p.320-326
Abstract
The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and... (More)
The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
type 1 diabetes, islet autoantibodies, HLA, virus
in
Annals of the New York Academy of Sciences
volume
1079
pages
320 - 326
publisher
Wiley-Blackwell
external identifiers
  • wos:000243126100049
  • scopus:33845701367
ISSN
0077-8923
DOI
10.1196/annals.1375.049
language
English
LU publication?
yes
id
617d1496-515e-4ba9-92c5-b877c990af9d (old id 679400)
date added to LUP
2016-04-01 15:47:04
date last changed
2022-03-30 03:03:07
@article{617d1496-515e-4ba9-92c5-b877c990af9d,
  abstract     = {{The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.}},
  author       = {{Hagopian, William A. and Lernmark, Åke and Rewers, Marian J. and Simell, Olli G. and She, Jin-Xiong and Ziegler, Anette G. and Krischer, Jeffrey P. and Akolkar, Beena}},
  issn         = {{0077-8923}},
  keywords     = {{type 1 diabetes; islet autoantibodies; HLA; virus}},
  language     = {{eng}},
  pages        = {{320--326}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Annals of the New York Academy of Sciences}},
  title        = {{TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial}},
  url          = {{http://dx.doi.org/10.1196/annals.1375.049}},
  doi          = {{10.1196/annals.1375.049}},
  volume       = {{1079}},
  year         = {{2006}},
}