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Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition

Agudo, Antonio; Sala, Nuria; Pera, Guillem; Capella, Gabriel; Berenguer, Antonio; Garcia, Nadia; Palli, Domenico; Boeing, Heiner; Del Giudice, Giuseppe and Saieva, Calogero, et al. (2006) In Cancer Epidemiology Biomarkers & Prevention 15(12). p.2427-2434
Abstract
Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of... (More)
Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C > A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G > A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
15
issue
12
pages
2427 - 2434
publisher
American Association for Cancer Research
external identifiers
  • wos:000242984400018
  • scopus:33846007251
ISSN
1538-7755
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English
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yes
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cd696f35-4258-4cb4-a0e2-3f22310c85e5 (old id 681916)
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2007-12-20 10:55:44
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2018-05-29 09:18:57
@article{cd696f35-4258-4cb4-a0e2-3f22310c85e5,
  abstract     = {Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C > A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G > A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis.},
  author       = {Agudo, Antonio and Sala, Nuria and Pera, Guillem and Capella, Gabriel and Berenguer, Antonio and Garcia, Nadia and Palli, Domenico and Boeing, Heiner and Del Giudice, Giuseppe and Saieva, Calogero and Carneiro, Fatima and Berrino, Franco and Sacerdote, Carlotta and Tumino, Rosario and Panico, Salvatore and Berglund, Göran and Simán, Henrik and Stenling, Roger and Hallmans, Goran and Martinez, Carmen and Bilbao, Roberto and Barricarte, Aurelio and Navarro, Carmen and Quiros, Jose R. and Allen, Naomi and Key, Tim and Bingham, Sheila and Khaw, Kay-Tee and Linseisen, Jakob and Nagel, Gabriele and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Bueno-de-Mesquita, H. Bas and Boshuizen, Hendriek C. and Peeters, Petra H. and Numans, Mattijs E. and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Trichopoulou, Antonia and Lund, Eiliv and Offerhaus, Johan and Jenab, Mazda and Ferrari, Pietro and Norat, Teresa and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {1538-7755},
  language     = {eng},
  number       = {12},
  pages        = {2427--2434},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/},
  volume       = {15},
  year         = {2006},
}