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Maternal plasma leptin levels in relation to the duration of the active phase of labor

Carlhäll, Sara ; Källén, Karin LU ; Thorsell, Annika and Blomberg, Marie (2018) In Acta Obstetricia et Gynecologica Scandinavica 97(10). p.1248-1256
Abstract

Introduction: Obese women have increased leptin levels and longer duration of labor compared with normal-weight women. Leptin has an inhibitory effect on myometrial contractility in vitro. Our purpose was to examine whether maternal leptin levels in active labor were associated with the duration of the active phase of labor. Material and methods: This prospective cohort study included 914 women. Maternal blood samples were collected in active labor. The plasma-leptin concentration was obtained using a direct sandwich-based ELISA. Bivariate and multiple linear regression analyses were used to study the association between leptin levels and the duration of labor. Results: A 1 ng/mL increase in maternal plasma leptin was associated with a... (More)

Introduction: Obese women have increased leptin levels and longer duration of labor compared with normal-weight women. Leptin has an inhibitory effect on myometrial contractility in vitro. Our purpose was to examine whether maternal leptin levels in active labor were associated with the duration of the active phase of labor. Material and methods: This prospective cohort study included 914 women. Maternal blood samples were collected in active labor. The plasma-leptin concentration was obtained using a direct sandwich-based ELISA. Bivariate and multiple linear regression analyses were used to study the association between leptin levels and the duration of labor. Results: A 1 ng/mL increase in maternal plasma leptin was associated with a 0.015 hour increase in duration of labor (P <.007). This association was not statistically significant in the adjusted analyses nor when analyzing nulliparous and multiparous women separately. In women with spontaneous labor (n = 766) leptin levels were not associated with an increase in duration of labor in the adjusted analyses. Conclusions: There was no significant association between leptin levels and duration of the active phase of labor. Leptin in vivo might display a similar dose-response effect on myometrial contractility as demonstrated in in vitro studies. Future studies need to explore the association between leptin levels and time in labor in obese women with high leptin levels to evaluate a possible dose-response effect.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
active phase of labor, delivery, duration of labor, leptin, obesity
in
Acta Obstetricia et Gynecologica Scandinavica
volume
97
issue
10
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85050360473
  • pmid:29772056
ISSN
0001-6349
DOI
10.1111/aogs.13380
language
English
LU publication?
yes
id
682bbd61-e015-4ea1-a30a-5748f8fb91cb
date added to LUP
2018-10-01 10:05:52
date last changed
2021-09-29 03:53:58
@article{682bbd61-e015-4ea1-a30a-5748f8fb91cb,
  abstract     = {<p>Introduction: Obese women have increased leptin levels and longer duration of labor compared with normal-weight women. Leptin has an inhibitory effect on myometrial contractility in vitro. Our purpose was to examine whether maternal leptin levels in active labor were associated with the duration of the active phase of labor. Material and methods: This prospective cohort study included 914 women. Maternal blood samples were collected in active labor. The plasma-leptin concentration was obtained using a direct sandwich-based ELISA. Bivariate and multiple linear regression analyses were used to study the association between leptin levels and the duration of labor. Results: A 1 ng/mL increase in maternal plasma leptin was associated with a 0.015 hour increase in duration of labor (P &lt;.007). This association was not statistically significant in the adjusted analyses nor when analyzing nulliparous and multiparous women separately. In women with spontaneous labor (n = 766) leptin levels were not associated with an increase in duration of labor in the adjusted analyses. Conclusions: There was no significant association between leptin levels and duration of the active phase of labor. Leptin in vivo might display a similar dose-response effect on myometrial contractility as demonstrated in in vitro studies. Future studies need to explore the association between leptin levels and time in labor in obese women with high leptin levels to evaluate a possible dose-response effect.</p>},
  author       = {Carlhäll, Sara and Källén, Karin and Thorsell, Annika and Blomberg, Marie},
  issn         = {0001-6349},
  language     = {eng},
  month        = {10},
  number       = {10},
  pages        = {1248--1256},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Maternal plasma leptin levels in relation to the duration of the active phase of labor},
  url          = {http://dx.doi.org/10.1111/aogs.13380},
  doi          = {10.1111/aogs.13380},
  volume       = {97},
  year         = {2018},
}