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Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study

Mendez, M. A.; Pera, Guillem; Aguclo, Antonio; Bueno-de-Mesquita, H. Bas; Palli, Domenico; Boeing, Heiner; Carneiro, Ftima; Berrino, Franco; Sacerdote, Carlotta and Tumino, Rosario, et al. (2007) In International Journal of Cancer 121(7). p.1618-1623
Abstract
Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prespective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires... (More)
Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prespective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships. (Less)
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publication status
published
subject
keywords
cohort study, cereal fiber, gastric cancer
in
International Journal of Cancer
volume
121
issue
7
pages
1618 - 1623
publisher
John Wiley & Sons
external identifiers
  • wos:000249109600028
  • scopus:34548284483
ISSN
0020-7136
DOI
10.1002/ijc.22896
language
English
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yes
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7b646e71-31d4-46ed-8a3d-5183443a86fd (old id 687994)
date added to LUP
2007-12-15 15:03:54
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2017-02-26 03:42:03
@article{7b646e71-31d4-46ed-8a3d-5183443a86fd,
  abstract     = {Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prespective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.},
  author       = {Mendez, M. A. and Pera, Guillem and Aguclo, Antonio and Bueno-de-Mesquita, H. Bas and Palli, Domenico and Boeing, Heiner and Carneiro, Ftima and Berrino, Franco and Sacerdote, Carlotta and Tumino, Rosario and Panico, Salvatore and Berglund, Goeran and Manjer, Jonas and Johansson, Ingegerd and Stenling, Roger and Martinez, Carmen and Dorronsoro, Miren and Barricarte, Aurelio and Tormo, Maria J. and Quiros, Jose R. and Allen, Naomi and Key, Timothy J. and Bingham, Sheila and Linseisen, Jakob and Kaaks, Rudolf and Overvad, Kim and Jensen, Majken and Olsen, Anja and Tjonneland, Anne and Peeters, Petra H. M. and Numans, Mattijs E. and Ocke, Marga C. and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Trichopoulou, Antonia and Lund, Eiliv and Slimani, Nadia and Jenab, Mazda and Ferrari, Pietro and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {0020-7136},
  keyword      = {cohort study,cereal fiber,gastric cancer},
  language     = {eng},
  number       = {7},
  pages        = {1618--1623},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study},
  url          = {http://dx.doi.org/10.1002/ijc.22896},
  volume       = {121},
  year         = {2007},
}