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Dose reduction and its influence on diagnostic accuracy and radiation risk in digital mammography: an observer performance study using an anthropomorphic breast phantom

Svahn, Tony LU ; Hemdal, Bengt LU ; Ruschin, Mark LU ; Chakraborty, D. P.; Andersson, Ingvar LU ; Tingberg, Anders LU and Mattsson, Sören LU (2007) In British Journal of Radiology 80(955). p.557-562
Abstract
This study aimed to investigate the effect of dose reduction on diagnostic accuracy and radiation risk in digital mammography. Simulated masses and microcalcifications were positioned in an anthropomorphic breast phantom. Thirty digital images, 14 with lesions, 16 without, were acquired of the phantom using a Mammomat Novation (Siemens, Erlangen, Germany) at each of three dose levels. These corresponded to 100%, 50% and 30% of the normally used average glandular dose (AGD; 1.3 mGy for a standard breast). Eight observers interpreted the 90 unprocessed images in a free response study, and the data were analysed with the jackknife free response receiver operating characteristic (JAFROC) method. Observer performance was assessed using the... (More)
This study aimed to investigate the effect of dose reduction on diagnostic accuracy and radiation risk in digital mammography. Simulated masses and microcalcifications were positioned in an anthropomorphic breast phantom. Thirty digital images, 14 with lesions, 16 without, were acquired of the phantom using a Mammomat Novation (Siemens, Erlangen, Germany) at each of three dose levels. These corresponded to 100%, 50% and 30% of the normally used average glandular dose (AGD; 1.3 mGy for a standard breast). Eight observers interpreted the 90 unprocessed images in a free response study, and the data were analysed with the jackknife free response receiver operating characteristic (JAFROC) method. Observer performance was assessed using the JAFROC figure of merit (FOM). The benefit of radiation risk reduction was estimated based on several risk models. There was no statistically significant difference in performance, as described by the FOM, between the 100% and the 50% dose levels. However, the FOMs for both the 100% and the 50% dose were significantly different from the corresponding quantity for the 30% dose level (F-statistic=4.95, p-value=0.01). A dose reduction of 50% would result in three to nine fewer breast cancer fatalities per 100 000 women undergoing annual screening from the age of 40 to 49 years. The results of the study indicate a possibility of reducing the dose to the breast to half the dose level currently used. This has to be confirmed in clinical studies, and possible differences depending on lesion type should be examined further. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Radiology
volume
80
issue
955
pages
557 - 562
publisher
British Inst Radiology
external identifiers
  • wos:000249239400008
  • scopus:34548311949
ISSN
1748-880X
DOI
10.1259/bjr/29933797
language
English
LU publication?
yes
id
1da241b8-32f4-474c-b542-d0f8c5eba7f4 (old id 688360)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17704316&dopt=Abstract
http://bjr.birjournals.org/cgi/content/full/80/955/557
date added to LUP
2007-12-20 16:05:35
date last changed
2017-01-01 06:47:32
@article{1da241b8-32f4-474c-b542-d0f8c5eba7f4,
  abstract     = {This study aimed to investigate the effect of dose reduction on diagnostic accuracy and radiation risk in digital mammography. Simulated masses and microcalcifications were positioned in an anthropomorphic breast phantom. Thirty digital images, 14 with lesions, 16 without, were acquired of the phantom using a Mammomat Novation (Siemens, Erlangen, Germany) at each of three dose levels. These corresponded to 100%, 50% and 30% of the normally used average glandular dose (AGD; 1.3 mGy for a standard breast). Eight observers interpreted the 90 unprocessed images in a free response study, and the data were analysed with the jackknife free response receiver operating characteristic (JAFROC) method. Observer performance was assessed using the JAFROC figure of merit (FOM). The benefit of radiation risk reduction was estimated based on several risk models. There was no statistically significant difference in performance, as described by the FOM, between the 100% and the 50% dose levels. However, the FOMs for both the 100% and the 50% dose were significantly different from the corresponding quantity for the 30% dose level (F-statistic=4.95, p-value=0.01). A dose reduction of 50% would result in three to nine fewer breast cancer fatalities per 100 000 women undergoing annual screening from the age of 40 to 49 years. The results of the study indicate a possibility of reducing the dose to the breast to half the dose level currently used. This has to be confirmed in clinical studies, and possible differences depending on lesion type should be examined further.},
  author       = {Svahn, Tony and Hemdal, Bengt and Ruschin, Mark and Chakraborty, D. P. and Andersson, Ingvar and Tingberg, Anders and Mattsson, Sören},
  issn         = {1748-880X},
  language     = {eng},
  number       = {955},
  pages        = {557--562},
  publisher    = {British Inst Radiology},
  series       = {British Journal of Radiology},
  title        = {Dose reduction and its influence on diagnostic accuracy and radiation risk in digital mammography: an observer performance study using an anthropomorphic breast phantom},
  url          = {http://dx.doi.org/10.1259/bjr/29933797},
  volume       = {80},
  year         = {2007},
}