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An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Pagani, Alberto; Pollastro, Federica; Spera, Silvia; Ballero, Mauro; Sterner, Olov LU and Appendino, Giovanni (2007) In Natural Product Communications 2(6). p.637-642
Abstract
A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SERCA, Thapsia garganica, neohelmanthicin D, thapsivillosin J, thapsigargin, thapsigargicin
in
Natural Product Communications
volume
2
issue
6
pages
637 - 642
publisher
Natural Products Inc
external identifiers
  • wos:000249007800004
  • scopus:78549265885
ISSN
1934-578X
language
English
LU publication?
yes
id
37274592-efd5-4e5a-a5cc-5ac46e2817a2 (old id 688887)
date added to LUP
2007-12-17 09:25:32
date last changed
2017-01-01 04:39:59
@article{37274592-efd5-4e5a-a5cc-5ac46e2817a2,
  abstract     = {A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.},
  author       = {Pagani, Alberto and Pollastro, Federica and Spera, Silvia and Ballero, Mauro and Sterner, Olov and Appendino, Giovanni},
  issn         = {1934-578X},
  keyword      = {SERCA,Thapsia garganica,neohelmanthicin D,thapsivillosin J,thapsigargin,thapsigargicin},
  language     = {eng},
  number       = {6},
  pages        = {637--642},
  publisher    = {Natural Products Inc},
  series       = {Natural Product Communications},
  title        = {An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin},
  volume       = {2},
  year         = {2007},
}