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Bladder and upper urinary tract cancers as first and second primary cancers

Zheng, Guoqiao LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU ; Hemminki, Otto and Hemminki, Kari LU (2021) In Cancer Reports
Abstract

Background: Previous population-based studies on second primary cancers (SPCs) in urothelial cancers have focused on known risk factors in bladder cancer patients without data on other urothelial sites of the renal pelvis or ureter. Aims: To estimate sex-specific risks for any SPCs after urothelial cancers, and in reverse order, for urothelial cancers as SPCs after any cancer. Such two-way analysis may help interpret the results. Methods: We employed standardized incidence ratios (SIRs) to estimate bidirectional relative risks of subsequent cancer associated with urothelial cancers. Patient data were obtained from the Swedish Cancer Registry from years 1990 through 2015. Results: We identified 46 234 urinary bladder cancers (75% male),... (More)

Background: Previous population-based studies on second primary cancers (SPCs) in urothelial cancers have focused on known risk factors in bladder cancer patients without data on other urothelial sites of the renal pelvis or ureter. Aims: To estimate sex-specific risks for any SPCs after urothelial cancers, and in reverse order, for urothelial cancers as SPCs after any cancer. Such two-way analysis may help interpret the results. Methods: We employed standardized incidence ratios (SIRs) to estimate bidirectional relative risks of subsequent cancer associated with urothelial cancers. Patient data were obtained from the Swedish Cancer Registry from years 1990 through 2015. Results: We identified 46 234 urinary bladder cancers (75% male), 940 ureteral cancers (60% male), and 2410 renal pelvic cancers (57% male). After male bladder cancer, SIRs significantly increased for 9 SPCs, most for ureteral (SIR 41.9) and renal pelvic (17.2) cancers. In the reversed order (bladder cancer as SPC), 10 individual FPCs were associated with an increased risk; highest associations were noted after renal pelvic (21.0) and ureteral (20.9) cancers. After female bladder cancer, SIRs of four SPCs were significantly increased, most for ureteral (87.8) and pelvic (35.7) cancers. Female bladder, ureteral, and pelvic cancers associated are with endometrial cancer. Conclusions: The risks of recurrent urothelial cancers were very high, and, at most sites, female risks were twice over the male risks. Risks persisted often to follow-up periods of >5 years, motivating an extended patient follow-up. Lynch syndrome-related cancers were associated with particularly female urothelial cancers, calling for clinical vigilance.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer etiology, relative risk, renal pelvic cancer, second primary cancer, ureter cancer, urothelial cancer
in
Cancer Reports
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85107551291
  • pmid:34114732
ISSN
2573-8348
DOI
10.1002/cnr2.1406
language
English
LU publication?
yes
id
6897c19d-d5e8-4750-91d3-127da17635af
date added to LUP
2021-07-06 12:10:07
date last changed
2024-06-15 13:15:21
@article{6897c19d-d5e8-4750-91d3-127da17635af,
  abstract     = {{<p>Background: Previous population-based studies on second primary cancers (SPCs) in urothelial cancers have focused on known risk factors in bladder cancer patients without data on other urothelial sites of the renal pelvis or ureter. Aims: To estimate sex-specific risks for any SPCs after urothelial cancers, and in reverse order, for urothelial cancers as SPCs after any cancer. Such two-way analysis may help interpret the results. Methods: We employed standardized incidence ratios (SIRs) to estimate bidirectional relative risks of subsequent cancer associated with urothelial cancers. Patient data were obtained from the Swedish Cancer Registry from years 1990 through 2015. Results: We identified 46 234 urinary bladder cancers (75% male), 940 ureteral cancers (60% male), and 2410 renal pelvic cancers (57% male). After male bladder cancer, SIRs significantly increased for 9 SPCs, most for ureteral (SIR 41.9) and renal pelvic (17.2) cancers. In the reversed order (bladder cancer as SPC), 10 individual FPCs were associated with an increased risk; highest associations were noted after renal pelvic (21.0) and ureteral (20.9) cancers. After female bladder cancer, SIRs of four SPCs were significantly increased, most for ureteral (87.8) and pelvic (35.7) cancers. Female bladder, ureteral, and pelvic cancers associated are with endometrial cancer. Conclusions: The risks of recurrent urothelial cancers were very high, and, at most sites, female risks were twice over the male risks. Risks persisted often to follow-up periods of &gt;5 years, motivating an extended patient follow-up. Lynch syndrome-related cancers were associated with particularly female urothelial cancers, calling for clinical vigilance.</p>}},
  author       = {{Zheng, Guoqiao and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Hemminki, Otto and Hemminki, Kari}},
  issn         = {{2573-8348}},
  keywords     = {{cancer etiology; relative risk; renal pelvic cancer; second primary cancer; ureter cancer; urothelial cancer}},
  language     = {{eng}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Cancer Reports}},
  title        = {{Bladder and upper urinary tract cancers as first and second primary cancers}},
  url          = {{http://dx.doi.org/10.1002/cnr2.1406}},
  doi          = {{10.1002/cnr2.1406}},
  year         = {{2021}},
}